| pubmed-article:6123018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C0085379 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C0856825 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C1550147 | lld:lifeskim |
| pubmed-article:6123018 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:6123018 | pubmed:issue | 8284 | lld:pubmed |
| pubmed-article:6123018 | pubmed:dateCreated | 1982-7-22 | lld:pubmed |
| pubmed-article:6123018 | pubmed:abstractText | Ten consecutive patients undergoing transplantation of bone marrow from histocompatible siblings for treatment of haematological malignancy took part in a pilot study to test the safety of in-vitro treatment of donor bone marrow with monoclonal antibody OKT3. Three male and seven female patients aged 7-34 years received concentrated bone marrow buffy-coat cells which had been incubated with OKT3 before infusion. In-vitro studies confirmed that almost all immunocompetent T lymphocytes in the bone-marrow samples were coated with OKT3 at the time of infusion. In vitro, neonatal rabbit complement inhibited the proliferation of bone-marrow T lymphocytes in samples preincubated with OKT3 to less than 4% of the mitogenic responses of the untreated bone marrow. In contrast, fresh autologous complement did not effectively lyse OKT3-treated bone-marrow cells. Infusion of OKT3-treated bone marrow was safely accomplished, and engraftment was achieved in all patients (mean 23 days). Nine of ten patients survived for more than 100 days after bone-marrow transplantation, but significant acute graft-versus-host disease (GvHD) requiring treatment with steroids developed in five of the ten. This finding suggests that further modifications for bone-marrow pretreatment will be needed to achieve effective prophylaxis against acute GvHD in histocompatible bone-marrow transplantation. | lld:pubmed |
| pubmed-article:6123018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6123018 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6123018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6123018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6123018 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6123018 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6123018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6123018 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6123018 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:GoldsteinGG | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:McGlaveP BPB | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:RamsayN KNK | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:WarkentinP... | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:FilipovichA... | lld:pubmed |
| pubmed-article:6123018 | pubmed:author | pubmed-author:KeseyJ HJH | lld:pubmed |
| pubmed-article:6123018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6123018 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:6123018 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:6123018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6123018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6123018 | pubmed:pagination | 1266-9 | lld:pubmed |
| pubmed-article:6123018 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:meshHeading | pubmed-meshheading:6123018-... | lld:pubmed |
| pubmed-article:6123018 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6123018 | pubmed:articleTitle | Pretreatment of donor bone marrow with monoclonal antibody OKT3 for prevention of acute graft-versus-host disease in allogeneic histocompatible bone-marrow transplantation. | lld:pubmed |
| pubmed-article:6123018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6123018 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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