| pubmed-article:6118133 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0034320 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C1881215 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:6118133 | lifeskim:mentions | umls-concept:C0993609 | lld:lifeskim |
| pubmed-article:6118133 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6118133 | pubmed:dateCreated | 1982-1-20 | lld:pubmed |
| pubmed-article:6118133 | pubmed:abstractText | The platelet content of PPi is 1.90 +/- mumol/10(11) platelets (S.E.M., n = 19) or about 10.5 nmol/mg of protein, several hundred times that found for rat liver. Some 80% of this PPi is secreted by platelets treated with thrombin with a time course and dose-response relationship similar to secretion of ATP, ADP and 5-hydroxytryptamine (serotonin) from the platelet dense granules. During platelet aggregation induced by ADP and adrenaline, substantial amounts of PPi were secreted, but no release of acid hydrolases was observed. Subcellular-fractionation studies showed that the PPi is highly enriched in the same fraction that contains the storage organelles which store ATP, ADP, Ca2+ and 5-hydroxytryptamine. Inorganic pyrophosphatase was present mainly in the soluble fraction and in the mitochondria. Secretion studies done with platelets prelabelled with [32P]Pi showed that the sequestered PPi was relatively metabolically inactive, as is the ATP and ADP in the storage organelles. The possible participation of PPi in the formation of a bivalent-cation-nucleotide complex associated with amine storage is discussed. | lld:pubmed |
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| pubmed-article:6118133 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6118133 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6118133 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6118133 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6118133 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6118133 | pubmed:author | pubmed-author:HolmsenHH | lld:pubmed |
| pubmed-article:6118133 | pubmed:author | pubmed-author:FukamiM HMH | lld:pubmed |
| pubmed-article:6118133 | pubmed:author | pubmed-author:BauerJ SJS | lld:pubmed |
| pubmed-article:6118133 | pubmed:author | pubmed-author:DangelmaierC... | lld:pubmed |
| pubmed-article:6118133 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6118133 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6118133 | pubmed:volume | 192 | lld:pubmed |
| pubmed-article:6118133 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6118133 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6118133 | pubmed:pagination | 99-105 | lld:pubmed |
| pubmed-article:6118133 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6118133 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6118133 | pubmed:articleTitle | Secretion, subcellular localization and metabolic status of inorganic pyrophosphate in human platelets. A major constituent of the amine-storing granules. | lld:pubmed |
| pubmed-article:6118133 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6118133 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6118133 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:5464 | entrezgene:pubmed | pubmed-article:6118133 | lld:entrezgene |
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