| pubmed-article:611659 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C1540912 | lld:lifeskim |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:611659 | lifeskim:mentions | umls-concept:C0808232 | lld:lifeskim |
| pubmed-article:611659 | pubmed:dateCreated | 1978-6-28 | lld:pubmed |
| pubmed-article:611659 | pubmed:abstractText | The Hypereosinophilic Syndrome (HES) is a disease of unknown etiology and pathogenesis characterized by blood and bone marrow eosinophilia associated with infiltration of eosinophils into tissues and multi-system organ dysfunction. Patients with HES historically have very significant morbidity and a high mortality of 77% at 3 years. This study is a prospective (9 years) and retrospective (24 years) analysis of the therapy and prognosis of 26 patients with HES. Five patients (19%) showed no evidence of progressive organ system dysfunction and were given no therapy; all have done well. Sixteen patients with progressive organ dysfunction were treated with corticosteroids; 6 of the 16 (38%) had a good response and required no further therapy. Six of 8 patients who were corticosteroid unresponsive and had serious prognostic signs had excellent responses to hydroxyurea therapy, while 2 patients showed partial responses. Employing the above regimen, we have demonstrated that our 26 patients (including 12 with poor prognostic indicators) have a marked increase in survival (3 year mortality 4%) when compared with the historical control. | lld:pubmed |
| pubmed-article:611659 | pubmed:language | eng | lld:pubmed |
| pubmed-article:611659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:611659 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:611659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:611659 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:611659 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:611659 | pubmed:issn | 0066-9458 | lld:pubmed |
| pubmed-article:611659 | pubmed:author | pubmed-author:WolffS MSM | lld:pubmed |
| pubmed-article:611659 | pubmed:author | pubmed-author:FauciA SAS | lld:pubmed |
| pubmed-article:611659 | pubmed:author | pubmed-author:ParrilloJ EJE | lld:pubmed |
| pubmed-article:611659 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:611659 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:611659 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:611659 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:611659 | pubmed:pagination | 135-44 | lld:pubmed |
| pubmed-article:611659 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-H... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-A... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-E... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-A... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-C... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-P... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-C... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-P... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-F... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-M... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-S... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-A... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-P... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-M... | lld:pubmed |
| pubmed-article:611659 | pubmed:meshHeading | pubmed-meshheading:611659-H... | lld:pubmed |
| pubmed-article:611659 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:611659 | pubmed:articleTitle | The hypereosinophilic syndrome: dramatic response to therapeutic intervention. | lld:pubmed |
| pubmed-article:611659 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:611659 | lld:pubmed |
