| pubmed-article:6097112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6097112 | lifeskim:mentions | umls-concept:C0034865 | lld:lifeskim |
| pubmed-article:6097112 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6097112 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:6097112 | lifeskim:mentions | umls-concept:C0005221 | lld:lifeskim |
| pubmed-article:6097112 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6097112 | pubmed:dateCreated | 1985-2-4 | lld:pubmed |
| pubmed-article:6097112 | pubmed:abstractText | Population genetic analysis of 15 restriction site polymorphisms demonstrates nonuniform recombination within the human beta-globin gene cluster. These DNA polymorphisms show two clusters of high nonrandom associations, one 5' and another 3' to the beta-globin structural gene, with no significant linkage disequilibrium between the two clusters. The 5'- and 3'-association clusters are 34.6 kilobases (kb) and 19.4 kb long, respectively, and are separated by 9.1 kb of DNA immediately 5' to the beta-globin gene. For each of these three DNA regions, we have observed a relationship between nonrandom associations and physical distance between the polymorphisms. However, this relationship differed for each of these regions. On the assumption that the effective population size (Ne) is 5,000-50,000, we estimate the total recombination rate to be 0.0017%-0.0002% in the 5' cluster, 0.0931%-0.0093% in the 3' cluster, and 0.2912%-0.0219% in the 9.1-kb region between them. The beta cluster thus shows nonuniformity in recombination. Moreover, the recombination rate in the 9.1-kb DNA segment is 3-30 times greater than expected and is thus a hot spot for meiotic recombination. | lld:pubmed |
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| pubmed-article:6097112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6097112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6097112 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6097112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6097112 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6097112 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:ChakravartiAA | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:KazazianH HHH | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:BuetowK HKH | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:AntonarakisS... | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:BoehmC DCD | lld:pubmed |
| pubmed-article:6097112 | pubmed:author | pubmed-author:WaberP GPG | lld:pubmed |
| pubmed-article:6097112 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6097112 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:6097112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6097112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6097112 | pubmed:pagination | 1239-58 | lld:pubmed |
| pubmed-article:6097112 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6097112 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6097112 | pubmed:articleTitle | Nonuniform recombination within the human beta-globin gene cluster. | lld:pubmed |
| pubmed-article:6097112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6097112 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6097112 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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