| pubmed-article:6095269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0206664 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0032403 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:6095269 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6095269 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:6095269 | pubmed:dateCreated | 1985-1-2 | lld:pubmed |
| pubmed-article:6095269 | pubmed:abstractText | Poly(ADP-ribose) synthesizing activity in mouse teratocarcinoma EC-A1 cells decreased markedly during differentiation induced by retinoic acid; the activities assayed in permeabilized cells decreased to 25% and 10% of the activity of control (uninduced cells) 2 and 3 days, respectively, after the addition of 0.1 microM retinoic acid to the culture medium. This change preceded changes in morphology and DNA synthesis, which became prominent after 4 days. The decrease in poly(ADP-ribose) synthesizing activity appeared to be caused by a diminution of the synthetase protein and not by a decrease in its catalytic activity, because the full activity disclosed by DNase I treatment decreased in parallel, albeit at about 20 times higher levels. When 8 mM 3-aminobenzamide or 10 mM nicotinamide, specific inhibitors of poly(ADP-ribose) synthetase, was added to the culture medium, the cells underwent differentiation after 7-9 days. An analogue, 3-aminobenzoic acid, which is not inhibitory to the synthetase, induced differentiation much less efficiently than did 3-aminobenzamide, and the effect of 3-aminobenzoic acid appeared to be ascribable to its potent cytotoxicity. Immunohistochemical analysis using anti-poly(ADP-ribose) antibody confirmed the marked reduction in poly(ADP-ribose) synthesizing activity in nuclei of the cells treated with retinoic acid or 3-aminobenzamide but not with 3-aminobenzoic acid. These results suggest that a decrease in poly(ADP-ribose) synthesis triggers differentiation of teratocarcinoma cells. | lld:pubmed |
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| pubmed-article:6095269 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6095269 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6095269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6095269 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6095269 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6095269 | pubmed:author | pubmed-author:HayaishiOO | lld:pubmed |
| pubmed-article:6095269 | pubmed:author | pubmed-author:UedaKK | lld:pubmed |
| pubmed-article:6095269 | pubmed:author | pubmed-author:OhashiYY | lld:pubmed |
| pubmed-article:6095269 | pubmed:author | pubmed-author:IkaiKK | lld:pubmed |
| pubmed-article:6095269 | pubmed:author | pubmed-author:NiwaOO | lld:pubmed |
| pubmed-article:6095269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6095269 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6095269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6095269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6095269 | pubmed:pagination | 7132-6 | lld:pubmed |
| pubmed-article:6095269 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6095269 | pubmed:meshHeading | pubmed-meshheading:6095269-... | lld:pubmed |
| pubmed-article:6095269 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6095269 | pubmed:articleTitle | Induction of murine teratocarcinoma cell differentiation by suppression of poly(ADP-ribose) synthesis. | lld:pubmed |
| pubmed-article:6095269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6095269 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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