pubmed-article:6095264 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6095264 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
pubmed-article:6095264 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
pubmed-article:6095264 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
pubmed-article:6095264 | pubmed:issue | 22 | lld:pubmed |
pubmed-article:6095264 | pubmed:dateCreated | 1985-1-2 | lld:pubmed |
pubmed-article:6095264 | pubmed:abstractText | Soluble extracts prepared from monkey cells (COS-1 or BSC-40) infected with simian virus 40 (SV40) catalyze the efficient replication of exogenously added plasmid DNA molecules containing the cloned SV40 origin of replication. Extracts prepared from uninfected monkey cells also support origin-dependent replication in vitro but only in the presence of added SV40 large tumor (T) antigen. Very little DNA synthesis is observed when the cloned viral origin contains a 4-base-pair deletion mutation known to abolish SV40 DNA replication in vivo or when the parental plasmid vector lacking SV40 sequences is employed as template. The in vitro replication reaction proceeds via branched intermediates (theta structures) that resemble in vivo replication intermediates. Replication is sensitive to aphidicolin but relatively resistant to dideoxythymidine triphosphate. The product of the reaction consists of covalently closed circular DNA molecules that contain full-length daughter strands hydrogen bonded to the parental template. These observations support the conclusion that replication in the in vitro system closely resembles SV40 DNA replication in vivo. The system provides a biochemical assay for the replication activity of SV40 T antigen and should also facilitate the purification and functional characterization of cellular proteins involved in DNA replication. | lld:pubmed |
pubmed-article:6095264 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:language | eng | lld:pubmed |
pubmed-article:6095264 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:6095264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6095264 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6095264 | pubmed:month | Nov | lld:pubmed |
pubmed-article:6095264 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:6095264 | pubmed:author | pubmed-author:EieHH | lld:pubmed |
pubmed-article:6095264 | pubmed:author | pubmed-author:KellyT JTJ | lld:pubmed |
pubmed-article:6095264 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6095264 | pubmed:volume | 81 | lld:pubmed |
pubmed-article:6095264 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6095264 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6095264 | pubmed:pagination | 6973-7 | lld:pubmed |
pubmed-article:6095264 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:meshHeading | pubmed-meshheading:6095264-... | lld:pubmed |
pubmed-article:6095264 | pubmed:year | 1984 | lld:pubmed |
pubmed-article:6095264 | pubmed:articleTitle | Simian virus 40 DNA replication in vitro. | lld:pubmed |
pubmed-article:6095264 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6095264 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6095264 | lld:pubmed |