| pubmed-article:6092629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:6092629 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:6092629 | pubmed:dateCreated | 1984-12-10 | lld:pubmed |
| pubmed-article:6092629 | pubmed:abstractText | The involvement of Ca2+ in the regulation of intestinal secretion was investigated in stripped sheets of rat mid-intestine. Removal of serosal Ca2+ together with the addition of EGTA at concentrations of 0.5 and 1 mM inhibited the rise in short-circuit current (s.c.c.) induced by both acetylcholine and theophylline, a similar degree of inhibition being observed with both secretagogues. Ca2+-free serosal fluid with 0.5 mM-EGTA added reduced significantly the rises in s.c.c. induced by A23187, acetylcholine, 5-hydroxytryptamine, theophylline, dibutyryl cyclic AMP and prostaglandin E2, but not the increased s.c.c. associated with glucose absorption. The Ca2+ channel blocker verapamil produced similar results. The calmodulin antagonist trifluoperazine inhibited secretagogue action while its sulphoxide derivative was without effect at the same concentration. The intracellular Ca2+ antagonist TMB-8 reduced the increased s.c.c. observed with acetylcholine and dibutyryl cyclic AMP. The net Cl- secretion, but not the decreased mucosal-to-serosal Na+ flux, induced by acetylcholine was abolished in Ca2+-free conditions. There was no consistent effect on the reduction in the residual ion flux caused by acetylcholine. Absence of Ca2+ converted the stimulation of Cl- secretion induced by dibutyryl cyclic AMP observed under control conditions to an enhancement of net Na+ and Cl- absorption. It is concluded that intestinal secretagogues, whether they act through cyclic AMP or not, require both internal and external sources of Ca2+ if they are to produce their full effects. Moreover, it appears that the nature of the response to dibutyryl cyclic AMP depends on the prevailing Ca2+ concentration. | lld:pubmed |
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| pubmed-article:6092629 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6092629 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6092629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6092629 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6092629 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6092629 | pubmed:author | pubmed-author:HardcastleJJ | lld:pubmed |
| pubmed-article:6092629 | pubmed:author | pubmed-author:HardcastleP... | lld:pubmed |
| pubmed-article:6092629 | pubmed:author | pubmed-author:NobleJ MJM | lld:pubmed |
| pubmed-article:6092629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6092629 | pubmed:volume | 355 | lld:pubmed |
| pubmed-article:6092629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6092629 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6092629 | pubmed:pagination | 465-78 | lld:pubmed |
| pubmed-article:6092629 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6092629 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6092629 | pubmed:articleTitle | The involvement of calcium in the intestinal response to secretagogues in the rat. | lld:pubmed |
| pubmed-article:6092629 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6092629 | pubmed:publicationType | In Vitro | lld:pubmed |
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