| pubmed-article:6087160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6087160 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:6087160 | lifeskim:mentions | umls-concept:C0031689 | lld:lifeskim |
| pubmed-article:6087160 | lifeskim:mentions | umls-concept:C1956003 | lld:lifeskim |
| pubmed-article:6087160 | lifeskim:mentions | umls-concept:C1418825 | lld:lifeskim |
| pubmed-article:6087160 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:6087160 | pubmed:issue | 5977 | lld:pubmed |
| pubmed-article:6087160 | pubmed:dateCreated | 1984-9-13 | lld:pubmed |
| pubmed-article:6087160 | pubmed:abstractText | The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a regional distribution in the mammalian brain very similar to that of dopamine-containing nerve terminals, being highly concentrated in the basal ganglia. The state of phosphorylation of DARPP-32 can be regulated by dopamine and by cyclic AMP in intact nerve cells, suggesting a role for this phosphoprotein in mediating certain of the effects of dopamine on dopaminoceptive cells. The observation that many of the physical and chemical properties of purified DARPP-32 resemble those of phosphatase inhibitor-1 (inhibitor-1), a widely distributed inhibitor of protein phosphatase-1, suggests that DARPP-32 might also function as a phosphatase inhibitor. We report here that DARPP-32 inhibits protein phosphatase-1 at nanomolar concentrations. Moreover, like inhibitor-1, DARPP-32 is effective as an inhibitor in its phosphorylated but not its dephosphorylated form. Thus, the basal ganglia of mammalian brain contain a region-specific neuronal phosphoprotein that is a protein phosphatase inhibitor. | lld:pubmed |
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| pubmed-article:6087160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6087160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6087160 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6087160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6087160 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6087160 | pubmed:author | pubmed-author:CohenPP | lld:pubmed |
| pubmed-article:6087160 | pubmed:author | pubmed-author:GreengardPP | lld:pubmed |
| pubmed-article:6087160 | pubmed:author | pubmed-author:TungH YHY | lld:pubmed |
| pubmed-article:6087160 | pubmed:author | pubmed-author:HemmingsH... | lld:pubmed |
| pubmed-article:6087160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6087160 | pubmed:volume | 310 | lld:pubmed |
| pubmed-article:6087160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6087160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6087160 | pubmed:pagination | 503-5 | lld:pubmed |
| pubmed-article:6087160 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6087160 | pubmed:articleTitle | DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. | lld:pubmed |
| pubmed-article:6087160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6087160 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6087160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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