| pubmed-article:6087138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C0022625 | lld:lifeskim |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C0023277 | lld:lifeskim |
| pubmed-article:6087138 | lifeskim:mentions | umls-concept:C1156542 | lld:lifeskim |
| pubmed-article:6087138 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6087138 | pubmed:dateCreated | 1984-9-10 | lld:pubmed |
| pubmed-article:6087138 | pubmed:abstractText | Ketoconazole, a clinically effective antimycotic agent active in vitro against the amastigote stage of Leishmania mexicana Walter Reed 227 in human monocyte-derived macrophages, was found to inhibit growth and impair sterol biosynthesis of the cultured promastigote stage by approx. 50% at a concentration of approx. 10(-8)M. Sterol biosynthesis was interfered with at the level of the removal of the 14 alpha-methyl group of lanosterol, as judged by changes in the distribution of [2-14C]mevalonate radioactivity among desmethyl sterol and methyl sterol thin-layer chromatography fractions, by the loss of 4-desmethyl sterols (mainly 5-dehydroepisterol), and by the accumulation of 14 alpha-methyl sterols. The growth inhibition and sterol changes were evident in promastigotes cultured in a cholesterol-rich medium and in a cholesterol-poor medium, even though promastigotes incorporated cholesterol. The mechanism of action of ketoconazole against promastigotes may be that postulated for Candida albicans: interference with membrane permeability secondary to loss of desmethyl sterols and accumulation of 14 alpha-methyl sterols. | lld:pubmed |
| pubmed-article:6087138 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6087138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6087138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6087138 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6087138 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6087138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6087138 | pubmed:month | May | lld:pubmed |
| pubmed-article:6087138 | pubmed:issn | 0166-6851 | lld:pubmed |
| pubmed-article:6087138 | pubmed:author | pubmed-author:HolzG GGGJr | lld:pubmed |
| pubmed-article:6087138 | pubmed:author | pubmed-author:BeachD HDH | lld:pubmed |
| pubmed-article:6087138 | pubmed:author | pubmed-author:BermanJ DJD | lld:pubmed |
| pubmed-article:6087138 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6087138 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:6087138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6087138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6087138 | pubmed:pagination | 1-13 | lld:pubmed |
| pubmed-article:6087138 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:meshHeading | pubmed-meshheading:6087138-... | lld:pubmed |
| pubmed-article:6087138 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6087138 | pubmed:articleTitle | Effects of ketoconazole on growth and sterol biosynthesis of Leishmania mexicana promastigotes in culture. | lld:pubmed |
| pubmed-article:6087138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6087138 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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