| pubmed-article:6086918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6086918 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:6086918 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:6086918 | lifeskim:mentions | umls-concept:C0022009 | lld:lifeskim |
| pubmed-article:6086918 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:6086918 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:6086918 | pubmed:dateCreated | 1984-9-19 | lld:pubmed |
| pubmed-article:6086918 | pubmed:abstractText | The membrane of tissue-cultured chick pectoral muscle contains an ionic channel which is activated by membrane stretch. Nicotinic channels and Ca2+-activated K+ channels are not affected by stretch. In 150 mM-external K+ and 150 mM-internal Na+ the channel has a conductance of 70 pS, linear current-voltage relationship between -50 and -140 mV and a reversal potential of +30 mV. Kinetic analysis of single-channel records indicates that there are one open (O) and three closed (C) states. The data can be fitted by the reaction scheme: C1-C2-C3-O. Only the rate constant that governs the C1-C2 transition (k1,2) is stretch-sensitive. None of the rates are voltage-sensitive. The rate constant k1,2 varies with the square of the tension as k1, 2 = k0 X e alpha T2, where alpha is a constant describing the sensitivity to stretch and T is the tension. A typical value of alpha is 0.08 (dyn cm-1)-2. Following exposure to cytochalasin B the channel becomes more sensitive to stretch. The stretch-sensitivity constant, alpha, increases from 0.08 to 2.4 (dyn cm-1)-2. The probability of the channel being open is strongly dependent upon the extracellular K+ concentration. With a suction of 2 cmHg the probability increases from 0.004 in normal saline (5 mM-K+) to 0.26 in 150 mM-K+. The channel appears to gather force from a large area of membrane (greater than 3 X 10(5) A2), probably by a cytochalasin-resistant cytoskeletal network. | lld:pubmed |
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| pubmed-article:6086918 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6086918 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6086918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6086918 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6086918 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6086918 | pubmed:author | pubmed-author:SachsFF | lld:pubmed |
| pubmed-article:6086918 | pubmed:author | pubmed-author:GuharayFF | lld:pubmed |
| pubmed-article:6086918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6086918 | pubmed:volume | 352 | lld:pubmed |
| pubmed-article:6086918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6086918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6086918 | pubmed:pagination | 685-701 | lld:pubmed |
| pubmed-article:6086918 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6086918 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6086918 | pubmed:articleTitle | Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. | lld:pubmed |
| pubmed-article:6086918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6086918 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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