| pubmed-article:6086904 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6086904 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:6086904 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:6086904 | lifeskim:mentions | umls-concept:C0085337 | lld:lifeskim |
| pubmed-article:6086904 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:6086904 | pubmed:dateCreated | 1984-9-12 | lld:pubmed |
| pubmed-article:6086904 | pubmed:abstractText | The membrane properties of a new mutant of Paramecium tetraurelia, dancer, were compared under voltage clamp with those of the wild type. The Ca2+ current was isolated and examined using CsCl-filled electrodes and tetraethylammonium in the bath solution to block K+ channels. The amplitude of the Ca2+ transient was not altered by the mutation. However, the Ca2+ current in the mutant inactivated more slowly and less extensively: hence a larger sustained Ca2+ current remained in the mutant. A change in the time course of the deactivation of the Ba2+ current was observed in the mutant. This mutational change is not likely to be the consequence of the Ca2+-channel inactivation because it is seen in the Ba2+ solution where there is little inactivation of the current. Other measured properties of the Ca2+ channel, the voltage-dependent K+ current, and the resting properties of the membrane were normal in the mutant. The Ca2+-activated K+ current and the Ca2+-activated Na+ current were larger in the mutant than in the wild type, consistent with a greater elevation of free intracellular Ca2+ during depolarization in the mutant. It is likely that the mutation causes an alteration in the Ca2+-channel structure or in its immediate environment and thereby affects the inactivation and deactivation processes of the Ca2+ channel. As would be expected from the greater Ca2+ current, the mutant tends to generate all-or-none Ca action potentials as opposed to the graded action potentials in the wild type. | lld:pubmed |
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| pubmed-article:6086904 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6086904 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6086904 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6086904 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6086904 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6086904 | pubmed:author | pubmed-author:SaimiYY | lld:pubmed |
| pubmed-article:6086904 | pubmed:author | pubmed-author:HinrichsenR... | lld:pubmed |
| pubmed-article:6086904 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6086904 | pubmed:volume | 351 | lld:pubmed |
| pubmed-article:6086904 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6086904 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6086904 | pubmed:pagination | 397-410 | lld:pubmed |
| pubmed-article:6086904 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6086904 | pubmed:meshHeading | pubmed-meshheading:6086904-... | lld:pubmed |
| pubmed-article:6086904 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6086904 | pubmed:articleTitle | A mutation that alters properties of the calcium channel in Paramecium tetraurelia. | lld:pubmed |
| pubmed-article:6086904 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6086904 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6086904 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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