| pubmed-article:6055758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C1817959 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C0175668 | lld:lifeskim |
| pubmed-article:6055758 | lifeskim:mentions | umls-concept:C0598148 | lld:lifeskim |
| pubmed-article:6055758 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6055758 | pubmed:dateCreated | 1967-12-27 | lld:pubmed |
| pubmed-article:6055758 | pubmed:abstractText | Upon immunization with LDH-III (subunit composition AABB) rabbits produce anti-A and anti-B antibodies in comparable amounts. These antibodies fit equally well to the hybrid enzyme and to LDH-V (AAAA) or LDH-I (BBBB) respectively, as tested by passive hemagglutination inhibition. No antibodies reacting with both LDH-I and LDH-V were detected. A minority of hybrid-specific antibodies was, however, present in the sera. Animals primed with LDH-III respond regularly to a boosting injection of LDH-V with the production of large amounts of anti-A (but not anti-B) antibodies. A similar injection of LDH-I stimulates (if it has any effect at all) the production of anti-B antibodies only. Stimulation with one of the pure types does not impair a subsequent response to the other. The majority of the animals primed with LDH-III responded not at all or weakly to a boosting injection of LDH-I, though antibodies to LDH-I were present in the sera at the time of stimulation. This effect can hardly be explained on the basis of serological sepcificity. Hyporesponsiveness to LDH-III can be induced by injection of LDH-V into the newborn. Both anti-A and anti-B titers are equally depressed. Within the dose range tested, LDH-I does not exert any tolerogenic action with respect to LDH-III. The carrier property of subunit A is evident in the induction of both immunity and tolerance to LDH-III. The early phase of the immune response to the hybrid enzyme may be carrier-specific, and receptors for the haptenic subunit B may not exist at that stage. | lld:pubmed |
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| pubmed-article:6055758 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6055758 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6055758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6055758 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6055758 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6055758 | pubmed:author | pubmed-author:RajewskyKK | lld:pubmed |
| pubmed-article:6055758 | pubmed:author | pubmed-author:MüllerBB | lld:pubmed |
| pubmed-article:6055758 | pubmed:author | pubmed-author:PeltreGG | lld:pubmed |
| pubmed-article:6055758 | pubmed:author | pubmed-author:RottländerEE | lld:pubmed |
| pubmed-article:6055758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6055758 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6055758 | pubmed:volume | 126 | lld:pubmed |
| pubmed-article:6055758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6055758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6055758 | pubmed:pagination | 581-606 | lld:pubmed |
| pubmed-article:6055758 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:6055758 | pubmed:year | 1967 | lld:pubmed |
| pubmed-article:6055758 | pubmed:articleTitle | The immune response to a hybrid protein molecule; specificity of secondary stimulation and of tolerance induction. | lld:pubmed |
| pubmed-article:6055758 | pubmed:publicationType | Journal Article | lld:pubmed |
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