| pubmed-article:6050971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6050971 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:6050971 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:6050971 | lifeskim:mentions | umls-concept:C0040682 | lld:lifeskim |
| pubmed-article:6050971 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:6050971 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:6050971 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:6050971 | pubmed:dateCreated | 1967-12-14 | lld:pubmed |
| pubmed-article:6050971 | pubmed:abstractText | The permeability of the membrane surfaces where cells are in contact (junctional membranes) in Chironomus salivary glands depends on Ca(++) and Mg(++). When the concentration of these ions at the junctional membranes is raised sufficiently, these normally highly permeable membranes seal off; their permeability falls one to three orders, as they approach the nonjunctional membranes in conductance. This permeability transformation is achieved in three ways: (a) by iontophoresis of Ca(++) into the cell; (b) by entry of Ca(++) and/or Mg(++) from the extracellular fluid into the cell through leaks in the cell surface membrane (e.g., injury); or (c) by entry of these ions through leaks arising, probably primarily in the perijunctional insulation, due to trypsin digestion, anisotonicity, alkalinity, or chelation. Ca(++) and Mg(++) appear to have three roles in the junctional coupling processes: (a) in the permeability of the junctional membranes; (b) in the permeability of the perijunctional insulation; and (c) a role long known- in the mechanical stability of the cell junction. The two latter roles may well be closely interdependent, but the first is clearly independent of the others. | lld:pubmed |
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| pubmed-article:6050971 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6050971 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6050971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6050971 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6050971 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:6050971 | pubmed:author | pubmed-author:LoewensteinW... | lld:pubmed |
| pubmed-article:6050971 | pubmed:author | pubmed-author:NakasMM | lld:pubmed |
| pubmed-article:6050971 | pubmed:author | pubmed-author:SocolarS JSJ | lld:pubmed |
| pubmed-article:6050971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6050971 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:6050971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6050971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6050971 | pubmed:pagination | 1865-91 | lld:pubmed |
| pubmed-article:6050971 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:6050971 | pubmed:year | 1967 | lld:pubmed |
| pubmed-article:6050971 | pubmed:articleTitle | Junctional membrane uncoupling. Permeability transformations at a cell membrane junction. | lld:pubmed |
| pubmed-article:6050971 | pubmed:publicationType | Journal Article | lld:pubmed |
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