| pubmed-article:5767057 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0684320 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0391845 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:5767057 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:5767057 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:5767057 | pubmed:dateCreated | 1969-4-18 | lld:pubmed |
| pubmed-article:5767057 | pubmed:abstractText | Rat mammary tumours induced by 7,12-dimethylbenz[a]anthracene can undergo repeated growth and regression during successive pregnancies. In a 10-day period after birth about half of the tumours regressed 50% or more. The concentrations of the lysosomal enzymes increased in regressing mammary tumours to the following multiples of the initial values: beta-glucuronidase, 7.7; beta-galactosidase, 3.9; cathepsin, 2.9; acid ribonuclease, 2.1; arylsulphatase A, 1.5; acid phosphatase, 1.4. In contrast, several non-lysosomal enzymes failed to increase. Activities in the post-partum uterus increased to the following multiples of the initial values: beta-glucuronidase, 5.8; cathepsin, 5.5; acid ribonuclease, 4.3; beta-galactosidase, 2.2; acid phosphatase, 1.8. Arylsulphatase A in the post-partum uterus decreased significantly, suggesting a non-lysosomal distribution or a special function related to pregnancy. No other significant changes were observed in the lysosomal or non-lysosomal enzymes in the hormone-independent liver or hormone-dependent normal mammary gland. The ratio of free to bound arylsulphatase A and acid ribonuclease decreased slightly 1-3 days after birth because of problems in homogenizing the tumours. At days 4-8, however, there was a dramatic increase in the ratio of the free to bound activities. The results can be explained in terms of the lysosomal theory of intracellular digestion. | lld:pubmed |
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| pubmed-article:5767057 | pubmed:language | eng | lld:pubmed |
| pubmed-article:5767057 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:5767057 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:5767057 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:5767057 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:5767057 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:5767057 | pubmed:author | pubmed-author:ShambergerR... | lld:pubmed |
| pubmed-article:5767057 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:5767057 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:5767057 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:5767057 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:5767057 | pubmed:pagination | 375-83 | lld:pubmed |
| pubmed-article:5767057 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:5767057 | pubmed:year | 1969 | lld:pubmed |
| pubmed-article:5767057 | pubmed:articleTitle | Lysosomal enzyme changes in growing and regressing mammary tumours. | lld:pubmed |
| pubmed-article:5767057 | pubmed:publicationType | Journal Article | lld:pubmed |
