| pubmed-article:558826 | pubmed:abstractText | The ultrastructural morphology of "free" cytoplasmic ribosomes of rat uterine epithelial cells was studied during diestrus, estrus, after ovariectomy, and after estradiol-17 beta administration to rats that were ovariectomized 1 to 25 weeks before hormone treatment. A change in size and contrast of ribosomes was observed concomitant with a transition from pre-existing monosomes to polysomes depending on the dose of estradiol and its route of application. In 3 weeks ovariectomized rats these changes in ribosomal granules take place at approximately the same time (30-45 min) when synthesis of "induced protein" was described biochemically. The morphological events after estradiol administration are discussed with respect to a primary site of estrogen action. | lld:pubmed |
