| pubmed-article:553327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0014544 | lld:lifeskim |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0025382 | lld:lifeskim |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0031412 | lld:lifeskim |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0683150 | lld:lifeskim |
| pubmed-article:553327 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:553327 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:553327 | pubmed:dateCreated | 1981-2-24 | lld:pubmed |
| pubmed-article:553327 | pubmed:abstractText | Plasma mephobarbital and phenobarbital concentrations were determined in 11 epileptic patients receiving mephobarbital alone or in combination with other antiepileptic drugs. The analysis was carried out by a selective ion monitoring (SIM) mass fragmentography technique following formation of N-propyl derivatives of both drugs. The plasma concentrations of phenobarbital ranged from 4 to 32 micrograms/ml and those of mephobarbital from 0.2 to 1.7 micrograms/ml. Differences in the metabolism rates of the drugs accounted for the plasma concentration differences; mephobarbital is metabolized more rapidly than phenobarbital. Phenobarbital concentrations obtained by SIM mass fragmentography were similar to those obtained by gas-liquid chromatographic on-column methylation, which quantitates only "total phenobarbital" (mephobarbital plus phenobarbital). | lld:pubmed |
| pubmed-article:553327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:553327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:553327 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:553327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:553327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:553327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:553327 | pubmed:issn | 0163-4356 | lld:pubmed |
| pubmed-article:553327 | pubmed:author | pubmed-author:KupferbergH... | lld:pubmed |
| pubmed-article:553327 | pubmed:author | pubmed-author:Longacre-Shaw... | lld:pubmed |
| pubmed-article:553327 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:553327 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:553327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:553327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:553327 | pubmed:pagination | 117-22 | lld:pubmed |
| pubmed-article:553327 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-H... | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-E... | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-P... | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-C... | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-M... | lld:pubmed |
| pubmed-article:553327 | pubmed:meshHeading | pubmed-meshheading:553327-G... | lld:pubmed |
| pubmed-article:553327 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:553327 | pubmed:articleTitle | Mephobarbital and phenobarbital plasma concentrations in epileptic patients treated with mephobarbital. | lld:pubmed |
| pubmed-article:553327 | pubmed:publicationType | Journal Article | lld:pubmed |
