Linked Life Data

5498494

Source:http://linkedlifedata.com/resource/pubmed/id/5498494

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pubmed-article:5498494pubmed:abstractText1. Kittens were raised for a period with one of their eyes closed by suture of the lids. The age at suture and the duration of deprivation were varied systematically. When the cat was a year or more old, the normal and deprived eyes were compared using behavioural procedures which made graded demands on visual function.2. In kittens deprived from birth, the duration of eye closure determined the severity of the defect in vision with the deprived eye. A cat with an eye closed for the first 4-6 weeks showed as a permanent effect only a lowering of the visual acuity. When closure was extended through the first 7 weeks the visual acuity was further lowered but the animal still showed good visual guidance of paw placement. Further extension of deprivation through the first 16 weeks led to a still more severe defect; such animals showed no indication of visual guidance of paw placement or of pattern discrimination. They were influenced visually by stimuli that differed in luminosity.3. The upper age limit of the susceptibility to deprivation was determined by varying the age at eye closure. Waiting until 1 month of age before closing the eye conferred no appreciable protection. Waiting until 2 months of age, however, reduced the damage. Deprivation starting at 4 months of age or later produced no effect we could detect. Thus, susceptibility is greatest during the second month after birth and then falls until by 4 months of age the kitten, like the adult cat, suffers no permanent consequences of monocular light and form deprivation.4. After exclusive use of the deprived eye for a period, brought about by closure of the normal eye, visual control with the deprived eye was better than in similarly deprived cats whose normal eye was never closed. Improvement in the deprived eye was also seen in an animal whose normal eye was closed after both eyes had been open for more than one year.5. Relating the behavioural results to the neurophysiological findings in the visual cortex in the same or similarly deprived cats shows that the grading of visual defects with age and length of deprivation was generally paralleled by a change in proportion of cortical cells driven by stimulation of the deprived eye. The effect of reversal of eye closure in improving behavioural control was not, however, accompanied by an increase in the ability of the deprived eye to drive cortical cells.lld:pubmed
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pubmed-article:5498494pubmed:authorpubmed-author:WieselT NTNlld:pubmed
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pubmed-article:5498494pubmed:volume206lld:pubmed
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pubmed-article:5498494pubmed:pagination437-55lld:pubmed
pubmed-article:5498494pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:5498494pubmed:year1970lld:pubmed
pubmed-article:5498494pubmed:articleTitleConsequences of monocular deprivation on visual behaviour in kittens.lld:pubmed
pubmed-article:5498494pubmed:publicationTypeJournal Articlelld:pubmed
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