pubmed-article:5338562 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:5338562 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
pubmed-article:5338562 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
pubmed-article:5338562 | pubmed:issue | 6 | lld:pubmed |
pubmed-article:5338562 | pubmed:dateCreated | 1967-8-14 | lld:pubmed |
pubmed-article:5338562 | pubmed:abstractText | DNA polymerases purified from several sources are characterized by replication of the 3'-hydroxy-terminated strand of a helical template. Failure to achieve simultaneous replication of the 5'-strand leads to aberrations in the synthesized DNA, described as nondenaturability and branching. Aberrations in synthesized DNA were not observed when (a) the 5'-strand was destroyed by a specific nuclease during the course of replication or (b) a single-stranded (circular) phage (M13) DNA served as template. Replication of a single-stranded, circular DNA produced a helical product, but the nature of initiation of a new strand by the circular template remains to be explained. Hypothetical mechanisms for simultaneous replication of the 5'-strand are presented as is the possibility that the tertiary structure of the DNA, as for example, a circular form of the helix, is of prime importance in in vivo replication. | lld:pubmed |
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pubmed-article:5338562 | pubmed:language | eng | lld:pubmed |
pubmed-article:5338562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:5338562 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:5338562 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:5338562 | pubmed:month | Jul | lld:pubmed |
pubmed-article:5338562 | pubmed:issn | 0022-1295 | lld:pubmed |
pubmed-article:5338562 | pubmed:author | pubmed-author:KornbergAA | lld:pubmed |
pubmed-article:5338562 | pubmed:author | pubmed-author:MitraSS | lld:pubmed |
pubmed-article:5338562 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:5338562 | pubmed:volume | 49 | lld:pubmed |
pubmed-article:5338562 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:5338562 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:5338562 | pubmed:pagination | 59-79 | lld:pubmed |
pubmed-article:5338562 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
pubmed-article:5338562 | pubmed:meshHeading | pubmed-meshheading:5338562-... | lld:pubmed |
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pubmed-article:5338562 | pubmed:meshHeading | pubmed-meshheading:5338562-... | lld:pubmed |
pubmed-article:5338562 | pubmed:year | 1966 | lld:pubmed |
pubmed-article:5338562 | pubmed:articleTitle | Enzymatic mechanisms of DNA replication. | lld:pubmed |
pubmed-article:5338562 | pubmed:publicationType | Journal Article | lld:pubmed |
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