| pubmed-article:500824 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0002006 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C1157324 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:500824 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:500824 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:500824 | pubmed:dateCreated | 1980-1-28 | lld:pubmed |
| pubmed-article:500824 | pubmed:abstractText | The effect of two prostaglandin synthesis inhibitors, indomethacin and meclofenamate, on angiotensin II (AII)- and III (AIII)-induced aldosterone release was studied in normal and sodium-depleted conscious rats and in adrenal capsular cell suspensions obtained from normal rats. In normal rats, in vivo AII and AIII were equipotent in causing dose-related increases in serum aldosterone concentrations. Indomethacin decreased the basal serum aldosterone levels by 50% and serum renin levels by 43%. In addition, the steroidogenic effects of AII and AIII were reduced by 45 and 63% with 3 mg/kg of indomethacin and 63 and 73% with 10 mg/kg, respectively. In contrast, meclofenamate failed to alter basal serum levels of aldosterone or AII-stimulated aldosterone release but inhibited serum renin levels by 27% and the aldosterone-stimulating effect of AIII by 99%. Indomethacin (3 mg/kg) and meclofenamate (2 mg/kg) inhibited urinary prostaglandin (PG)E(2) and PGF(2alpha) excretion by 63 and 52% and 37 and 31%, respectively. Both inhibitors significantly decreased the adrenal capsular PGE(2) and PGF(2alpha) content and the conversion of [(14)C]arachidonate to [(14)C]PGE(2) and [(14)C]PGF(2alpha). In sodium-depleted rats, indomethacin produced similar effects reducing the control serum aldosterone levels by 29%, AII-stimulated aldosterone by 47%, and completely suppressing the aldosterone response to AIII without altering serum renin activity. In adrenal cell suspensions, similar results were observed with indomethacin inhibiting basal and AII- and AIII-stimulated aldosterone release by 29, 81, and 93%, respectively. Meclofenamate failed to alter basal and AII-stimulated aldosterone release but inhibited that stimulated by AIII by 86%. The present findings suggest that prostaglandins modulate the effects of the renin-angiotensin system by stimulating the release of renin from the kidney and augmenting the steroidogenic effects of AII and AIII in the adrenal cortex. | lld:pubmed |
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| pubmed-article:500824 | pubmed:language | eng | lld:pubmed |
| pubmed-article:500824 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:500824 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:500824 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:500824 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:500824 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:500824 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:500824 | pubmed:author | pubmed-author:CampbellW BWB | lld:pubmed |
| pubmed-article:500824 | pubmed:author | pubmed-author:ItskovitzH... | lld:pubmed |
| pubmed-article:500824 | pubmed:author | pubmed-author:Gomez-Sanchez... | lld:pubmed |
| pubmed-article:500824 | pubmed:author | pubmed-author:SchmitzJ MJM | lld:pubmed |
| pubmed-article:500824 | pubmed:author | pubmed-author:AdamsB VBV | lld:pubmed |
| pubmed-article:500824 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:500824 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:500824 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:500824 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:500824 | pubmed:pagination | 1552-7 | lld:pubmed |
| pubmed-article:500824 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:500824 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:500824 | pubmed:articleTitle | Attenuation of angiotensin II- and III-induced aldosterone release by prostaglandin synthesis inhibitors. | lld:pubmed |
| pubmed-article:500824 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:500824 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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