| pubmed-article:4986482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C0016047 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C1704970 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:4986482 | lifeskim:mentions | umls-concept:C0004400 | lld:lifeskim |
| pubmed-article:4986482 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:4986482 | pubmed:dateCreated | 1970-7-6 | lld:pubmed |
| pubmed-article:4986482 | pubmed:abstractText | Incorporation of (3)H-thymidine by BSC-1 cells infected with Shope fibroma virus was studied by means of high-resolution electron microscopic radioautography. One-hour pulses with the radioactive precursor were given at various times after infection, during a one-step growth cycle of the virus. In the cytoplasm of infected cells, reacted grains occurred over foci of viroplasm; these foci are believed to represent the true sites of viral deoxyribonucleic acid (DNA) replication. Shope fibroma virus DNA synthesis began before 3 hr postinfection, reached a maximum at 8 to 9 hr, and then declined rapidly. It was demonstrated that the decline in (3)H-thymidine uptake is correlated with the onset of viral morphogenesis. In comparison with the noninfected culture, the nuclear labeling, which reflects host DNA metabolism, was slightly reduced by 4 hr postinfection. Inhibition became more marked as infection progressed, and host DNA synthesis was almost completely suppressed in late stages of viral development. | lld:pubmed |
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| pubmed-article:4986482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4986482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4986482 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4986482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4986482 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:4986482 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:4986482 | pubmed:author | pubmed-author:ScherrerRR | lld:pubmed |
| pubmed-article:4986482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4986482 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:4986482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4986482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4986482 | pubmed:pagination | 1418-28 | lld:pubmed |
| pubmed-article:4986482 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4986482 | pubmed:year | 1968 | lld:pubmed |
| pubmed-article:4986482 | pubmed:articleTitle | Viral and host deoxyribonucleic acid synthesis in Shope fibroma virus-infected cells as studied by means of high-resolution autoradiography. | lld:pubmed |
| pubmed-article:4986482 | pubmed:publicationType | Journal Article | lld:pubmed |
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