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| pubmed-article:4881701 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:4881701 | lifeskim:mentions | umls-concept:C0003993 | lld:lifeskim |
| pubmed-article:4881701 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:4881701 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:4881701 | pubmed:dateCreated | 1969-1-31 | lld:pubmed |
| pubmed-article:4881701 | pubmed:abstractText | l-Asparaginase II was synthesized at constant rates by Escherichia coli under anaerobic conditions. The enzyme was produced optimally by bacteria grown between pH 7 and 8 at 37 C. Although some enzyme was formed aerobically, between 100 and 1,000 times more asparaginase II was produced during anaerobic growth in media enriched with high concentrations of a variety of amino acids. Bacteria grown under these conditions should provide a rich starting material for the large-scale production of the enzyme. No single amino acid specifically induced the synthesis of the asparaginase, nor did l-asparagine, even when it was used as the only source of nitrogen. The enzyme was produced at lower rates in the presence of sugars; glucose was the most inhibitory. | lld:pubmed |
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| pubmed-article:4881701 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4881701 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4881701 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4881701 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4881701 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:4881701 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:4881701 | pubmed:author | pubmed-author:SchwartzJ HJH | lld:pubmed |
| pubmed-article:4881701 | pubmed:author | pubmed-author:CedarHH | lld:pubmed |
| pubmed-article:4881701 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4881701 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:4881701 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4881701 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4881701 | pubmed:pagination | 2043-8 | lld:pubmed |
| pubmed-article:4881701 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4881701 | pubmed:year | 1968 | lld:pubmed |
| pubmed-article:4881701 | pubmed:articleTitle | Production of L-asparaginase II by Escherichia coli. | lld:pubmed |
| pubmed-article:4881701 | pubmed:publicationType | Journal Article | lld:pubmed |
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