| pubmed-article:4854919 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0031456 | lld:lifeskim |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:4854919 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:4854919 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4854919 | pubmed:dateCreated | 1974-10-24 | lld:pubmed |
| pubmed-article:4854919 | pubmed:abstractText | Phenylalanine hydroxylase was prepared from human foetal liver and purified 800-fold; it appeared to be essentially pure. The phenylalanine hydroxylase activity of the liver was confined to a single protein of mol.wt. approx. 108000, but omission of a preliminary filtration step resulted in partial conversion into a second enzymically active protein of mol.wt. approx. 250000. Human adult and full-term infant liver also contained a single phenylalanine hydroxylase with molecular weights and kinetic parameters the same as those of the foetal enzyme; foetal, newborn and adult phenylalanine hydroxylase are probably identical. The K(m) values for phenylalanine and cofactor were respectively one-quarter and twice those found for rat liver phenylalanine hydroxylase. As with the rat enzyme, human phenylalanine hydroxylase acted also on p-fluorophenylalanine, which was inhibitory at high concentrations, and p-chlorophenylalanine acted as an inhibitor competing with phenylalanine. Iron-chelating and copper-chelating agents inhibited human phenylalanine hydroxylase. Thiol-binding reagents inhibited the enzyme but, as with the rat enzyme, phenylalanine both stabilized the human enzyme and offered some protection against these inhibitors. It is hoped that isolation of the normal enzyme will further the study of phenylketonuria. | lld:pubmed |
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| pubmed-article:4854919 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4854919 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4854919 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4854919 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4854919 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:4854919 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4854919 | pubmed:author | pubmed-author:WooS LSL | lld:pubmed |
| pubmed-article:4854919 | pubmed:author | pubmed-author:WoolfL ILI | lld:pubmed |
| pubmed-article:4854919 | pubmed:author | pubmed-author:GillamS SSS | lld:pubmed |
| pubmed-article:4854919 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4854919 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:4854919 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4854919 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4854919 | pubmed:pagination | 741-9 | lld:pubmed |
| pubmed-article:4854919 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4854919 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4854919 | pubmed:articleTitle | The isolation and properties of phenylalanine hydroxylase from human liver. | lld:pubmed |
| pubmed-article:4854919 | pubmed:publicationType | Journal Article | lld:pubmed |
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