| pubmed-article:4705642 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4705642 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:4705642 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:4705642 | lifeskim:mentions | umls-concept:C0007580 | lld:lifeskim |
| pubmed-article:4705642 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:4705642 | lifeskim:mentions | umls-concept:C0439536 | lld:lifeskim |
| pubmed-article:4705642 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:4705642 | pubmed:dateCreated | 1973-7-19 | lld:pubmed |
| pubmed-article:4705642 | pubmed:abstractText | The effects of ionic strength and cationic valency of the fluid medium on the surface potential and dextran-induced aggregation of red blood cells (RBC's) were investigated. The zeta potential was calculated from cell mobility in a microelectrophoresis apparatus; the degree of aggregation of normal and neuraminidase-treated RBC's in dextrans (Dx 40 and Dx 80) was quantified by microscopic observation, measurement of erythrocyte sedimentation rate, and determination of low-shear viscosity. A decrease in ionic strength caused a reduction in aggregation of normal RBC's in dextrans, but had no effect on the aggregation of neuraminidase-treated RBC's. These findings reflect an increase in electrostatic repulsive force between normal RBC's by the reduction in ionic strength due to (a) a decrease in the screening of surface charge by counter-ions and (b) an increase in the thickness of the electric double layer. Divalent cations (Ca(++), Mg(++), and Ba(++)) increased aggregation of normal RBC's in dextrans, but had no effect on the aggregation of neuraminidase-treated RBC's. These effects of the divalent cations are attributable to a decrease in surface potential of normal RBC's and a shrinkage of the electric double layer. It is concluded that the surface charge of RBC's plays a significant role in cell-to-cell interactions. | lld:pubmed |
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| pubmed-article:4705642 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4705642 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4705642 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4705642 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4705642 | pubmed:month | May | lld:pubmed |
| pubmed-article:4705642 | pubmed:issn | 0022-1295 | lld:pubmed |
| pubmed-article:4705642 | pubmed:author | pubmed-author:ChienSS | lld:pubmed |
| pubmed-article:4705642 | pubmed:author | pubmed-author:JanK MKM | lld:pubmed |
| pubmed-article:4705642 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4705642 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:4705642 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4705642 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4705642 | pubmed:pagination | 655-68 | lld:pubmed |
| pubmed-article:4705642 | pubmed:dateRevised | 2010-6-22 | lld:pubmed |
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| pubmed-article:4705642 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4705642 | pubmed:articleTitle | Influence of the ionic composition of fluid medium on red cell aggregation. | lld:pubmed |
| pubmed-article:4705642 | pubmed:publicationType | Journal Article | lld:pubmed |
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