pubmed-article:468987 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0006726 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0042866 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
pubmed-article:468987 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
pubmed-article:468987 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:468987 | pubmed:dateCreated | 1979-10-26 | lld:pubmed |
pubmed-article:468987 | pubmed:abstractText | Intestinal calcium absorption assessed by a double-isotope method, decreased significantly with aging in 94 normal subjects (r = -0.22, P < 0.025). In 52 untreated patients with postmenopausal osteoporosis, calcium absorption was significantly lower than normal when either age or habitual calcium intake was used as a covariable (P < 0.001). Serum 25-hydroxyvitamin D (25-OH-D) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) were measured in 44 normal subjects and 27 osteoporotic patients. For all normals, calcium absorption and serum 1,25(OH)(2)D were positively correlated (r = 0.50, P < 0.001). In nonelderly normal subjects (ages 30-65 yr), dietary calcium intake correlated inversely with both calcium absorption (r = -0.39, P < 0.01) and with serum 1,25(OH)(2)D (r = -0.50, P < 0.01). Both osteoporotic patients and elderly normal subjects (ages 65-90 yr) differed from nonelderly normals in that these correlations were not present. In addition although serum 25-OH-D was normal, serum 1,25(OH)(2)D was significantly decreased in both osteoporotic patients and elderly normals (P < 0.001). In osteoporotic patients, calcium absorption increased significantly (P < 0.001) after 7 d administration of a small dose (0.4 mug/d) of synthetic 1,25(OH)(2)D(3). In osteoporotics mean serum immunoreactive parathyroid hormone was either normal (COOH-terminal assay) or low (NH(2)-terminal assay) relative to age-matched controls, and mean serum phosphate was increased. The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH)(2)D contributes significantly to decreased calcium absorption and adaptation in both osteoporotics and elderly normal subjects. In patients with osteoporosis this abnormality could result from a decrease in factors that normally stimulate 1,25(OH)(2)D production, such as the decreased parathyroid hormone secretion and increased serum phosphate demonstrated in this group. In elderly subjects a primary abnormality in metabolism of 25-OH-D to 1,25(OH)(2)D, analagous to that seen in aging rats, cannot be excluded. | lld:pubmed |
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pubmed-article:468987 | pubmed:language | eng | lld:pubmed |
pubmed-article:468987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:468987 | pubmed:citationSubset | AIM | lld:pubmed |
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pubmed-article:468987 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:468987 | pubmed:month | Sep | lld:pubmed |
pubmed-article:468987 | pubmed:issn | 0021-9738 | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:DeLucaH FHF | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:ArnaudS BSB | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:GallagherJ... | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:EismanJJ | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:RiggsB LBL | lld:pubmed |
pubmed-article:468987 | pubmed:author | pubmed-author:HamstraAA | lld:pubmed |
pubmed-article:468987 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:468987 | pubmed:volume | 64 | lld:pubmed |
pubmed-article:468987 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:468987 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:468987 | pubmed:pagination | 729-36 | lld:pubmed |
pubmed-article:468987 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:468987 | pubmed:year | 1979 | lld:pubmed |
pubmed-article:468987 | pubmed:articleTitle | Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. | lld:pubmed |
pubmed-article:468987 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:468987 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:468987 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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