| pubmed-article:4679725 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4679725 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:4679725 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:4679725 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:4679725 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:4679725 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:4679725 | pubmed:dateCreated | 1974-12-18 | lld:pubmed |
| pubmed-article:4679725 | pubmed:abstractText | 1. The voltage-clamp technique was used to separate the effects of K depletion in the T-system from the decline in K permeability during hyperpolarization, and to characterize the time- and voltage-dependence of the latter.2. K permeability due to the inward rectifier can be described as being proportional to a parameter which diminishes when the membrane is hyperpolarized beyond -120 mV. The parameter obeys first-order kinetics. At 24 degrees C, it can change with a time constant of 49 msec at -150 mV and 25 msec at -65 mV. At -200 mV the fall in membrane conductance due to the permeability change is to 30% of its initial value. The Q(10) for the rate of conductance change at that potential is about 2.8.3. It is estimated that K inward current can lower the average K concentration in the T-system by more than 50%, and that, on the average, the space enclosed by the T-system should be less than 0.8% of the fibre volume. Assuming the T-system space to be 0.3% of the fibre volume, it is calculated that on the average, and during hyperpolarization to about -150 mV, no more than 20% of the initial current should flow across the surface membrane. | lld:pubmed |
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| pubmed-article:4679725 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4679725 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4679725 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4679725 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4679725 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:4679725 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:4679725 | pubmed:author | pubmed-author:AlmersWW | lld:pubmed |
| pubmed-article:4679725 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4679725 | pubmed:volume | 225 | lld:pubmed |
| pubmed-article:4679725 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4679725 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4679725 | pubmed:pagination | 57-83 | lld:pubmed |
| pubmed-article:4679725 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:4679725 | pubmed:year | 1972 | lld:pubmed |
| pubmed-article:4679725 | pubmed:articleTitle | The decline of potassium permeability during extreme hyperpolarization in frog skeletal muscle. | lld:pubmed |
| pubmed-article:4679725 | pubmed:publicationType | Journal Article | lld:pubmed |
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