| pubmed-article:4573363 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C1337112 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C0242864 | lld:lifeskim |
| pubmed-article:4573363 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:4573363 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:4573363 | pubmed:dateCreated | 1973-6-25 | lld:pubmed |
| pubmed-article:4573363 | pubmed:abstractText | During nonpermissive infection by a T7 amber mutant in gene 1 (phage RNA polymerase-deficient), synthesis of the products of the phage genes 3 (endonuclease), 3, 5 (lysozyme), 5 (DNA polymerase), and 17 (serum blocking power) was shown to occur at about half the rate as during wild-type infection. This relatively high rate of expression of "late" genes (transcribed normally by the phage RNA polymerase) seems to be a general feature of all T7 mutants in gene 1 from our collection. In contrast, T3 gene 1 mutants and a T7 gene 1 mutant from another collection showed late protein synthesis at very reduced rates. Synthesis of the gene 3 endonuclease by T7 gene 1 mutants was very sensitive to the addition of rifampin 2 min after infection, conditions under which there was very little inhibition during wild-type infection. This supports the notion that late gene expression during nonpermissive infection by gene 1 mutants is dependent on the transcription of the T7 genome by the host RNA polymerase. In contrast to T3 gene 1 mutants, the T7 gene 1 mutants of our collection directed the synthesis of phage DNA during nonpermissive infection. This DNA accumulated as a material sedimenting faster than mature T7 DNA. | lld:pubmed |
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| pubmed-article:4573363 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4573363 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4573363 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4573363 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4573363 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4573363 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:4573363 | pubmed:author | pubmed-author:IssingerO GOG | lld:pubmed |
| pubmed-article:4573363 | pubmed:author | pubmed-author:HausmannRR | lld:pubmed |
| pubmed-article:4573363 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4573363 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:4573363 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4573363 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4573363 | pubmed:pagination | 465-72 | lld:pubmed |
| pubmed-article:4573363 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4573363 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4573363 | pubmed:articleTitle | Synthesis of bacteriophage-coded gene products during infection of Escherichia coli with amber mutants of T3 and T7 defective in gene 1. | lld:pubmed |
| pubmed-article:4573363 | pubmed:publicationType | Journal Article | lld:pubmed |
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