| pubmed-article:4570017 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0024262 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:4570017 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:4570017 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4570017 | pubmed:dateCreated | 1973-5-1 | lld:pubmed |
| pubmed-article:4570017 | pubmed:abstractText | A population of thymus-derived lymphocytes has been identified that, upon activation by the nonspecific plant mitogen concanavalin A, suppresses the development of plaque-forming cell responses in fresh or 48-h antigen-stimulated cultures of mouse spleen cells. Suppressor cells can inhibit both primary and secondary IgM and IgG responses in vitro. X-irradiation before activation of peripheral thymus-derived cells by concanavalin A abrogates generation of suppressor cells. After a 48 h activation period, however, the function of concanavalin A-activated suppressor cells is radioresistant. As yet uncertain is whether these suppressor cells are a population of cells distinct from thymus-derived "helper" cells. In certain important regards, the cells mediating these two opposing functions share similar characteristics; the effect observed may be determined by the circumstances of activation or the numbers of activated cells, and may consequently represent different functions of a single thymus-derived regulator cell population. | lld:pubmed |
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| pubmed-article:4570017 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4570017 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:4570017 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4570017 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:4570017 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:4570017 | pubmed:author | pubmed-author:PierceC WCW | lld:pubmed |
| pubmed-article:4570017 | pubmed:author | pubmed-author:RichR RRR | lld:pubmed |
| pubmed-article:4570017 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4570017 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:4570017 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:4570017 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4570017 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4570017 | pubmed:pagination | 649-59 | lld:pubmed |
| pubmed-article:4570017 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:4570017 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4570017 | pubmed:articleTitle | Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes. | lld:pubmed |
| pubmed-article:4570017 | pubmed:publicationType | Journal Article | lld:pubmed |
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