| pubmed-article:4542575 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4542575 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:4542575 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:4542575 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:4542575 | lifeskim:mentions | umls-concept:C0001479 | lld:lifeskim |
| pubmed-article:4542575 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4542575 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:4542575 | pubmed:dateCreated | 1973-11-30 | lld:pubmed |
| pubmed-article:4542575 | pubmed:abstractText | 1. Insulin increased the rate of net Na extrusion from Na-loaded frog skeletal muscle into glucose-free Na-Ringer. After a 90 min period of efflux, the insulin-treated muscles contained approximately 11% less intracellular water than did their controls. This decrease in intracellular water resulted in an increase in the concentration of intracellular K, [K(+)](i), even though there was no definite effect upon net K flux. In spite of the decrease in intracellular water, [Na(+)](i) was lower in those muscles treated with 500 m-u. insulin/ml. than in the controls.2. Insulin consistently increased (22)Na efflux into Na-Ringer containing either 10 or 2.5 mM-K(+). This effect was reversible and was not produced by other proteins.3. Acetylstrophanthidin (5 x 10(-6)M) blocked all or nearly all net Na efflux even in the presence of insulin. The presence of this concentration of acetylstrophanthidin or of K-free Na-Ringer inhibited the effect of insulin upon (22)Na efflux from Na-loaded muscles.4. All of the above results indicate that insulin in some way increases the activity of the Na pump. The inhibition by K-free Na-Ringer also suggests that this is not due to production of additional pump sites.5. Insulin also increased (22)Na efflux and net sodium efflux into Li-Ringer. When the new steady-state was reached after addition of insulin, the (22)Na kinetics still obeyed a power relation to intracellular (22)Na. However, in every single case, insulin resulted in a decrease of approximately 18% in the exponent, n.6. Curve-fitting of the kinetic data to equations based upon a three-site model of the Na pump suggests that insulin increases the affinity of the sites toward Na(+). In terms of Eisenman's theory of ion selectivity, this would indicate an increase in the anionic field strength of the Na-carrying sites and also predict that the increase in affinity for H(+) would be greater than that for Na(+). This latter prediction is entirely consistent with the observed decrease in n.7. The results suggest that insulin may be increasing H(+) efflux as well as Na(+) efflux and thereby may be increasing intracellular pH. It is suggested that some of the intracellular effects of insulin might be mediated by such an effect. | lld:pubmed |
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| pubmed-article:4542575 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4542575 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4542575 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4542575 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:4542575 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:4542575 | pubmed:author | pubmed-author:MooreR DRD | lld:pubmed |
| pubmed-article:4542575 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4542575 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:4542575 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4542575 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4542575 | pubmed:pagination | 23-45 | lld:pubmed |
| pubmed-article:4542575 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:4542575 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4542575 | pubmed:articleTitle | Effect of insulin upon the sodium pump in frog skeletal muscle. | lld:pubmed |
| pubmed-article:4542575 | pubmed:publicationType | Journal Article | lld:pubmed |
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