| pubmed-article:4502947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0035286 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0030943 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:4502947 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:4502947 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:4502947 | pubmed:dateCreated | 1972-7-20 | lld:pubmed |
| pubmed-article:4502947 | pubmed:abstractText | IF-M(2), one of three initiation factors isolated by DEAE-cellulose chromatography from the 0.5 M KCl-wash fraction of rabbit reticulocyte ribosomes, has been separated by Sephadex G-200 chromatography into two components: IF-M(2A) and IF-M(2B). IF-M(2A) elutes near the void-volume, while IF-M(2B), which is much smaller in molecular weight than IF-M(2A), elutes slightly after a hemoglobin marker. In the presence of the other appropriate factors, both IF-M(2A) and IF-M(2B) are required to stimulate poly(U)-directed polyphenylalanine synthesis at low Mg(++) concentration, ApUpG-directed Met-tRNA(F) binding to washed reticulocyte ribosomes, and initiation of globin synthesis from endogenous mRNA. IF-M(2A) stimulates ribosome-dependent GTP hydrolysis, while IF-M(2B) does not; IF-M(2B) stimulates ApUpG-directed fMet-tRNA(F) binding in the presence of IF-M(1), while IF-M(2A) does not. Although IF-M(2A) and IF-M(2B) can be distinguished from each other by size and by activity, a distinct function for IF-M(2B) has not yet been found. Therefore, its precise role in the initiation process remains unclear. | lld:pubmed |
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| pubmed-article:4502947 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4502947 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4502947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4502947 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4502947 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:4502947 | pubmed:author | pubmed-author:AndersonW FWF | lld:pubmed |
| pubmed-article:4502947 | pubmed:author | pubmed-author:MerrickW CWC | lld:pubmed |
| pubmed-article:4502947 | pubmed:author | pubmed-author:GilbertJ MJM | lld:pubmed |
| pubmed-article:4502947 | pubmed:author | pubmed-author:ShafritzD ADA | lld:pubmed |
| pubmed-article:4502947 | pubmed:author | pubmed-author:PrichardP MPM | lld:pubmed |
| pubmed-article:4502947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4502947 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:4502947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4502947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4502947 | pubmed:pagination | 983-7 | lld:pubmed |
| pubmed-article:4502947 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:4502947 | pubmed:year | 1972 | lld:pubmed |
| pubmed-article:4502947 | pubmed:articleTitle | Separation of reticulocyte initiation factor M 2 activity into two components. | lld:pubmed |
| pubmed-article:4502947 | pubmed:publicationType | Journal Article | lld:pubmed |
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