| pubmed-article:447836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C0024297 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:447836 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:447836 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:447836 | pubmed:dateCreated | 1979-8-16 | lld:pubmed |
| pubmed-article:447836 | pubmed:abstractText | Human macrophages, derived from peripheral blood monocytes, acquire enhanced cytotoxicity for human target cells after incubation in mediator-rich supernates from antigen-stimulated lymphocytes. Maximum cytotoxicity was observed after 24-h incubation in mediators. In comparison to normal macrophages, mediator-activated macrophages were cytotoxic to five of the six malignant cell lines tested but had no effect on five nonmalignant cell lines. In 20 experiments with one target (SK-BR-3), mean cytotoxicity was 23 +/- 2.7% and with another target (MA-160), was 29 +/- 3.4%. Macrophages became cytotoxic after 8-h incubation with mediators and the enhanced cytotoxicity persisted for at least 40 h after the lymphocyte mediators were removed. These findings are consistent with the hypothesis that macrophages, activated by antigen-induced lymphocyte mediators, can contribute to the host resistance to tumor growth in man. | lld:pubmed |
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| pubmed-article:447836 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:447836 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:447836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:447836 | pubmed:month | May | lld:pubmed |
| pubmed-article:447836 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:447836 | pubmed:author | pubmed-author:ChurchillW... | lld:pubmed |
| pubmed-article:447836 | pubmed:author | pubmed-author:CameronD JDJ | lld:pubmed |
| pubmed-article:447836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:447836 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:447836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:447836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:447836 | pubmed:pagination | 977-84 | lld:pubmed |
| pubmed-article:447836 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:447836 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:447836 | pubmed:articleTitle | Cytotoxicity of human macrophages for tumor cells. Enhancement by human lymphocyte mediators. | lld:pubmed |
| pubmed-article:447836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:447836 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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