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| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C0002921 | lld:lifeskim |
| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C0205345 | lld:lifeskim |
| pubmed-article:4392560 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:4392560 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:4392560 | pubmed:dateCreated | 1970-6-15 | lld:pubmed |
| pubmed-article:4392560 | pubmed:abstractText | 1. Alprenolol, a beta-adrenoceptor blocking drug reported to have the same potency as propranolol in vitro and in vivo, was found to be four times more active than procaine as a local anaesthetic on frog sciatic nerve.2. At doses of 0.125 mg/kg and above alprenolol protected anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation.3. In isolated rabbit atria, resting potentials were unchanged, and the duration of the action potential was not prolonged, by concentrations of alprenolol up to 10.5 x 10(-6)M. The maximum rate of depolarization (MRD), however, was reduced by 30% at a concentration of 0.525 x 10(-6)M. This was 214 times less than the concentration which reduced the frog action potential height by 25%.4. The concentration of alprenolol required to produce more than 15% decrease in contraction or maximum driven frequency was 3.5 x 10(-6)M.5. As a test of the direct action of alprenolol on isolated cardiac muscle, MRD was also a more sensitive test than the measurement of electrical threshold or conduction velocity. | lld:pubmed |
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| pubmed-article:4392560 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4392560 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4392560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4392560 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4392560 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:4392560 | pubmed:author | pubmed-author:SinghB NBN | lld:pubmed |
| pubmed-article:4392560 | pubmed:author | pubmed-author:WilliamsE MEM | lld:pubmed |
| pubmed-article:4392560 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4392560 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:4392560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4392560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4392560 | pubmed:pagination | 749-57 | lld:pubmed |
| pubmed-article:4392560 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4392560 | pubmed:year | 1970 | lld:pubmed |
| pubmed-article:4392560 | pubmed:articleTitle | Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle. | lld:pubmed |
| pubmed-article:4392560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4392560 | pubmed:publicationType | In Vitro | lld:pubmed |
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