| pubmed-article:4377211 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:4377211 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:4377211 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4377211 | pubmed:dateCreated | 1975-10-30 | lld:pubmed |
| pubmed-article:4377211 | pubmed:abstractText | The soluble activity in lymphocytes which converts phosphatidylinositol into 1,2-diacylglycerol and inositol phosphates requires Ca(2+) ions. At pH7 maximum activity occurs at [Ca(2+)](free) approximately 0.7mum whereas at pH5.5 the equivalent value is approx. 50mum. At [Ca(2+)](free) approximately 1mum, a concentration similar to common intracellular values, essentially all activity is confined to the peak of activity at pH7.0. Previous reports of requirements for larger amounts of Ca(2+) may reflect the fact that the Ca(2+)-buffering capacity of phosphatidylinositol means that high substrate concentrations can effectively decrease [Ca(2+)](free). Cations which displace Ca(2+) from association with phosphatidylinositol can, at low [Ca(2+)](free), enhance enzyme activity. Phosphatidylinositol breakdown in intact cells might be controlled, at least in part, by changes in intracellular [Ca(2+)](free). | lld:pubmed |
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| pubmed-article:4377211 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4377211 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4377211 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4377211 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:4377211 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4377211 | pubmed:author | pubmed-author:AllanDD | lld:pubmed |
| pubmed-article:4377211 | pubmed:author | pubmed-author:MichellR HRH | lld:pubmed |
| pubmed-article:4377211 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4377211 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:4377211 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4377211 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4377211 | pubmed:pagination | 599-604 | lld:pubmed |
| pubmed-article:4377211 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4377211 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4377211 | pubmed:articleTitle | Phosphatidylinositol cleavage in lymphocytes. Requirement for calcium ions at a low concentration and effects of other cations. | lld:pubmed |
| pubmed-article:4377211 | pubmed:publicationType | Journal Article | lld:pubmed |
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