| pubmed-article:4317857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4317857 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:4317857 | lifeskim:mentions | umls-concept:C0025575 | lld:lifeskim |
| pubmed-article:4317857 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:4317857 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:4317857 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:4317857 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:4317857 | pubmed:dateCreated | 1970-10-5 | lld:pubmed |
| pubmed-article:4317857 | pubmed:abstractText | 1. Experiments were conducted to determine the influence of the rate of noradrenaline synthesis on the conversion of alpha-methyl-m-tyrosine to metaraminol.2. Male Wistar rats, 175-200 g, were placed into four groups and treated with (1) alpha-methyl-p-tyrosine methyl ester, 250 mg/kg; (2) DL-alpha-methyl-m-tyrosine, 400 mg/kg; (3) alpha-methyl-p-tyrosine methyl ester, 250 mg/kg plus DL-alpha-methyl-m-tyrosine, 400 mg/kg; or (4) an equivalent volume of injection vehicle. All solutions were injected intraperitoneally.3. Immediately after treatment half of the rats were transferred to 4 degrees C with the remaining animals being kept at 27 degrees C.4. The rats were killed 4, 8 and 12 h after injection, the brains, hearts, spleens and adrenals removed and analysed for adrenaline, noradrenaline, metaraminol and alpha-methyl-m-tyramine.5. In virtually all cases, both during rest (27 degrees C) and sympathetic stress (4 degrees C), treatment of the rats with alpha-methyl-p-tyrosine methyl ester increased the amount of metaraminol formed from alpha-methyl-m-tyrosine. The only organ not containing increased quantities of metaraminol in the presence of alpha-methyl-p-tyrosine methyl ester was the adrenals, taken from the rats kept at 27 degrees C. Adrenals removed from the cold-exposed rats contained more metaraminol when alpha-methyl-p-tyrosine methyl ester was combined with alpha-methyl-m-tyrosine than when alpha-methyl-m-tyrosine was used alone.6. These results demonstrate that the inhibition of noradrenaline synthesis, by treatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine methyl ester, increased the conversion of alpha-methyl-m-tyrosine to metaraminol. It is concluded that inhibiting the formation of dopa allowed increased amounts of alpha-methyl-m-tyrosine to enter the biosynthetic pathway. These results support the false sympathetic transmitter concept advanced for metaraminol. | lld:pubmed |
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| pubmed-article:4317857 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4317857 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4317857 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4317857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4317857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4317857 | pubmed:month | May | lld:pubmed |
| pubmed-article:4317857 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:4317857 | pubmed:author | pubmed-author:PugsleyT ATA | lld:pubmed |
| pubmed-article:4317857 | pubmed:author | pubmed-author:JohnsonG EGE | lld:pubmed |
| pubmed-article:4317857 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4317857 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:4317857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4317857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4317857 | pubmed:pagination | 167-74 | lld:pubmed |
| pubmed-article:4317857 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4317857 | pubmed:year | 1970 | lld:pubmed |
| pubmed-article:4317857 | pubmed:articleTitle | Studies on the interrelationship between the syntheses of noradrenaline and metaraminol. | lld:pubmed |
| pubmed-article:4317857 | pubmed:publicationType | Journal Article | lld:pubmed |
