| pubmed-article:4313200 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4313200 | lifeskim:mentions | umls-concept:C0001492 | lld:lifeskim |
| pubmed-article:4313200 | lifeskim:mentions | umls-concept:C0031436 | lld:lifeskim |
| pubmed-article:4313200 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:4313200 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:4313200 | lifeskim:mentions | umls-concept:C1512498 | lld:lifeskim |
| pubmed-article:4313200 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:4313200 | pubmed:dateCreated | 1970-3-27 | lld:pubmed |
| pubmed-article:4313200 | pubmed:abstractText | Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyroid hormone stimulation of kidney preparations was not inhibited under these conditions. At chlorpromazine concentrations >3 x 10(-4)M F(-)-stimulated cyclase activity of thyroid and adrenal tissue was increased. Other phenothiazines, trifluoperazine, and prochlorperazine, have similar effects on thyrotropin and F(-)-stimulated cyclase activity of thyroid. Na(+)- K(+)-dependent ATPase of thyroid is also inhibited by chlorpromazine. Since thymol causes a similar dissociation of hormone- and F(-)-stimulated adenyl cyclase, it is concluded that the surface properties of these agents best account for their effects on adenyl cyclase. | lld:pubmed |
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| pubmed-article:4313200 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4313200 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4313200 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4313200 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:4313200 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:4313200 | pubmed:author | pubmed-author:WolfeMM | lld:pubmed |
| pubmed-article:4313200 | pubmed:author | pubmed-author:JonesA BAB | lld:pubmed |
| pubmed-article:4313200 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4313200 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:4313200 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4313200 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4313200 | pubmed:pagination | 454-9 | lld:pubmed |
| pubmed-article:4313200 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4313200 | pubmed:year | 1970 | lld:pubmed |
| pubmed-article:4313200 | pubmed:articleTitle | Inhibition of hormone-sensitive adenyl cyclase by phenothiazines. | lld:pubmed |
| pubmed-article:4313200 | pubmed:publicationType | Journal Article | lld:pubmed |
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