Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:428009rdf:typepubmed:Citationlld:pubmed
pubmed-article:428009lifeskim:mentionsumls-concept:C0003927lld:lifeskim
pubmed-article:428009lifeskim:mentionsumls-concept:C0013901lld:lifeskim
pubmed-article:428009lifeskim:mentionsumls-concept:C0456387lld:lifeskim
pubmed-article:428009lifeskim:mentionsumls-concept:C0243077lld:lifeskim
pubmed-article:428009lifeskim:mentionsumls-concept:C0442821lld:lifeskim
pubmed-article:428009pubmed:issue2lld:pubmed
pubmed-article:428009pubmed:dateCreated1979-6-29lld:pubmed
pubmed-article:428009pubmed:abstractTextEllipticine (E) and its 9-hydroxy derivative inhibit strongly various liver monooxygenase activities mediated by microsomes from control and phenobarbital (PB), benzo[alpha]pyrene (BP) or Aroclor 1254 (Aroclor)-pretreated rats. The inhibition constants, Ki, are remarkably low, and often smaller than 1 micron, particularly in the case of microsomes containing cytochrome P-448. The inhibitory potency (I50) of 9-hydroxyellipticine (9-OHE) is larger (about ten-fold) than the one of classical inhibitors (metyrapone or 7,8-benzoflavone (7,8-BF)), whatever the activities studied and the induction of microsomes. Differences exist between the mechanisms of inhibition according to the form of cytochrome P-450 present in microsomes of differently pretreated rats; whichever the activities studied, one observes: (a) a competitive inhibition towards the activity of non-induced or PB-induced microsomes and (b) a non-competitive inhibition towards the activity of Aroclor or BP-induced microsomes, at variance with 7,8-BF. These results are in good agreement with the interaction properties of the ellipticines with microsomal cytochromes P-450.lld:pubmed
pubmed-article:428009pubmed:languageenglld:pubmed
pubmed-article:428009pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:citationSubsetIMlld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:428009pubmed:statusMEDLINElld:pubmed
pubmed-article:428009pubmed:monthFeblld:pubmed
pubmed-article:428009pubmed:issn0009-2797lld:pubmed
pubmed-article:428009pubmed:authorpubmed-author:LescaPPlld:pubmed
pubmed-article:428009pubmed:authorpubmed-author:MansuyDDlld:pubmed
pubmed-article:428009pubmed:authorpubmed-author:LecointePPlld:pubmed
pubmed-article:428009pubmed:authorpubmed-author:RafidinarivoE...lld:pubmed
pubmed-article:428009pubmed:issnTypePrintlld:pubmed
pubmed-article:428009pubmed:volume24lld:pubmed
pubmed-article:428009pubmed:ownerNLMlld:pubmed
pubmed-article:428009pubmed:authorsCompleteYlld:pubmed
pubmed-article:428009pubmed:pagination189-97lld:pubmed
pubmed-article:428009pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-A...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-O...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-R...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-A...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-M...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-K...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-M...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-M...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-B...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-D...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-A...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-C...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-A...lld:pubmed
pubmed-article:428009pubmed:meshHeadingpubmed-meshheading:428009-E...lld:pubmed
pubmed-article:428009pubmed:year1979lld:pubmed
pubmed-article:428009pubmed:articleTitleA class of strong inhibitors of microsomal monooxygenases: the ellipticines.lld:pubmed
pubmed-article:428009pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:428009lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:428009lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:428009lld:pubmed