| pubmed-article:4156361 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4156361 | lifeskim:mentions | umls-concept:C0036126 | lld:lifeskim |
| pubmed-article:4156361 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:4156361 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:4156361 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:4156361 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:4156361 | pubmed:dateCreated | 1975-6-21 | lld:pubmed |
| pubmed-article:4156361 | pubmed:abstractText | A mutation of Salmonella typhimurium was obtained that results in the failure of cells to synthesize the enzyme l-histidine ammonia-lyase (histidase). The mutation mapped within the hutH gene and in merodiploid strains was dominant over the wild-type allele. Extracts from cells bearing the trans-dominant histidase-negative allele were shown to contain material that reacts immunologically with antiserum against purified wild-type histidase. It is proposed that the trans-dominant allele results in the synthesis of defective histidase subunits that can combine with, and partially inactivate, wild-type histidase subunits. This subunit mixing presumably does occur, as the enzyme synthesized in a hybrid merodiploid strain is abnormally heat sensitive. | lld:pubmed |
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| pubmed-article:4156361 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4156361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4156361 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4156361 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4156361 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:4156361 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:4156361 | pubmed:author | pubmed-author:MagasanikBB | lld:pubmed |
| pubmed-article:4156361 | pubmed:author | pubmed-author:HagenD CDC | lld:pubmed |
| pubmed-article:4156361 | pubmed:author | pubmed-author:LiptonP JPJ | lld:pubmed |
| pubmed-article:4156361 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4156361 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:4156361 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4156361 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4156361 | pubmed:pagination | 906-16 | lld:pubmed |
| pubmed-article:4156361 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4156361 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4156361 | pubmed:articleTitle | Isolation of a trans-dominant histidase-negative mutant of Salmonella typhimurium. | lld:pubmed |
| pubmed-article:4156361 | pubmed:publicationType | Journal Article | lld:pubmed |
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