pubmed-article:4154497 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:4154497 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
pubmed-article:4154497 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
pubmed-article:4154497 | lifeskim:mentions | umls-concept:C0001645 | lld:lifeskim |
pubmed-article:4154497 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
pubmed-article:4154497 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
pubmed-article:4154497 | pubmed:issue | 4170 | lld:pubmed |
pubmed-article:4154497 | pubmed:dateCreated | 1975-2-18 | lld:pubmed |
pubmed-article:4154497 | pubmed:abstractText | An iodine-labeled beta-adrenergic inhibitor ((125)l-hydroxybenzylpindolol) binds specifically to a site on turkey erythrocyte membranes. A series of beta-adrenergic agonists and inhibitors compete for this binding site, with apparent affinities paralleling biological effectiveness as activators or inhibitors of catecholaminestimulated adenylate cyclase. The activity of d-(+) agonists or inhibitors was 1 percent (or less) than that of the corresponding l-(-) isomers in competing for binding of the iodinated blocker as well as in affecting catecholamine-stimulated adenylate cyclase. 1-(-)-Norepinephrine was about one-tenth as active as l-(-)-isoproterenol in competing for the beta-blocking agent site. The stereospecificity of the interaction with the iodinated beta-blocking agent and the correspondence between affinity for site and biological potency of analogs suggested that this interaction is involved in function of the beta-adrenergic receptor. | lld:pubmed |
pubmed-article:4154497 | pubmed:language | eng | lld:pubmed |
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pubmed-article:4154497 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:4154497 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:4154497 | pubmed:month | Dec | lld:pubmed |
pubmed-article:4154497 | pubmed:issn | 0036-8075 | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:AurbachG DGD | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:HauserDD | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:WoodardC JCJ | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:PalmerJ SJS | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:FedakS ASA | lld:pubmed |
pubmed-article:4154497 | pubmed:author | pubmed-author:TroxlerFF | lld:pubmed |
pubmed-article:4154497 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:4154497 | pubmed:day | 27 | lld:pubmed |
pubmed-article:4154497 | pubmed:volume | 186 | lld:pubmed |
pubmed-article:4154497 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:4154497 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:4154497 | pubmed:pagination | 1223-4 | lld:pubmed |
pubmed-article:4154497 | pubmed:dateRevised | 2009-10-27 | lld:pubmed |
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pubmed-article:4154497 | pubmed:year | 1974 | lld:pubmed |
pubmed-article:4154497 | pubmed:articleTitle | Beta-adrenergic receptor: stereospecific interaction of iodinated beta-blocking agent with high affinity site. | lld:pubmed |
pubmed-article:4154497 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:4154497 | pubmed:publicationType | In Vitro | lld:pubmed |
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