| pubmed-article:4062402 | pubmed:abstractText | During a six-year period (1979 to 1984), the technique of hypothermic circulatory arrest was used to operate on 128 patients. Our technique included induction of hypothermia (20 degrees to 24 degrees C) by femoral artery cannulation for return of oxygenated blood, "open" aortic reconstruction, and brief periods of circulatory arrest (range, 5 to 31 minutes; mean, 13 minutes). Eighty patients had dissecting aneurysms of the ascending aorta (42 acute, 38 chronic), 28 had fusiform aortic arch aneurysms, and 13 had annulo-aortic ectasia. Seven had other procedures. Ages ranged from 14 to 79 years (mean, 54 years). Of the 113 patients (88%) who survived the operation and were discharged, 107 are currently alive and well. Only 15 of the 21 deaths occurred within 30 days of operation, and 5 (33%) were in severely hypotensive patients whose operations were begun during active resuscitation. Of the 80 patients admitted with ascending aortic or arch dissection, an in-hospital mortality of 7.5% was achieved. A marked reduction was observed in such complications as postoperative hemorrhage, renal failure, and pulmonary insufficiency with our current hypothermic perfusion methods. Moreover, none of the five neurological complications could be attributed to anoxic cerebral injury during the period of circulatory arrest. This experience indicates that moderate levels of hypothermia provide adequate cerebral protection for most cardiovascular procedures, and our results encourage continued use of this method. | lld:pubmed |
