| pubmed-article:4060577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0007125 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:4060577 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:4060577 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:4060577 | pubmed:dateCreated | 1985-12-11 | lld:pubmed |
| pubmed-article:4060577 | pubmed:abstractText | The exposure of cells to interferons enhances the accumulation of particular mRNAs and of the corresponding proteins. A cDNA clone (clone 202) complementary to an mRNA (202 mRNA) whose level is enhanced over 12-fold in mouse Ehrlich ascites tumor cells upon exposure to beta-interferon for 10 hr has previously been isolated. The level of this mRNA was also increased in other beta-interferon-responsive mouse cell lines (i.e., L929, L1210S) but not in a line (L1210R) which is not responsive to beta-interferon. The extent of induction in Ehrlich ascites tumor cells depended on the beta-interferon concentration and reached its maximal level between 300 and 1000 units of interferon/ml. Nuclei isolated from Ehrlich ascites tumor cells which had been exposed to beta-interferon produced in vitro more 202 specific RNA than nuclei from control Ehrlich ascites tumor cells: an increase in this production was detectable 2 hr after beginning the exposure of the cells to 1000 units/ml of beta-interferon and the increase reached its maximal level, around 18-fold, after 18 hr exposure. Much, if not all of this increase, appeared to be due to an increase in the rate of synthesis of the RNA and not to a decrease in its rate of turnover. The 202 mRNA was translated in a reticulocyte lysate into a 56,000-Da protein. | lld:pubmed |
| pubmed-article:4060577 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4060577 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4060577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4060577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4060577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4060577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:4060577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4060577 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4060577 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:4060577 | pubmed:author | pubmed-author:LengyelPP | lld:pubmed |
| pubmed-article:4060577 | pubmed:author | pubmed-author:SamantaHH | lld:pubmed |
| pubmed-article:4060577 | pubmed:author | pubmed-author:EngelD ADA | lld:pubmed |
| pubmed-article:4060577 | pubmed:author | pubmed-author:BrawnerM EME | lld:pubmed |
| pubmed-article:4060577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4060577 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:4060577 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:4060577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4060577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4060577 | pubmed:pagination | 389-97 | lld:pubmed |
| pubmed-article:4060577 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:4060577 | pubmed:meshHeading | pubmed-meshheading:4060577-... | lld:pubmed |
| pubmed-article:4060577 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4060577 | pubmed:articleTitle | Interferon action: transcriptional control of a gene specifying a 56,000-Da protein in Ehrlich ascites tumor cells. | lld:pubmed |
| pubmed-article:4060577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4060577 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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