| pubmed-article:40585 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0000618 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0004482 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:40585 | lifeskim:mentions | umls-concept:C0597573 | lld:lifeskim |
| pubmed-article:40585 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:40585 | pubmed:dateCreated | 1980-1-28 | lld:pubmed |
| pubmed-article:40585 | pubmed:abstractText | 1 A simple, specific assay for 6-mercaptopurine (6-MP) in human plasma with a sensitivity of 10 ng/ml (66 nmol/1) has been developed. 2 6-MP was extracted directly from plasma into toluene using a novel extraction procedure. This involves conversion of 6-MP into a phenyl mercury derivative by its reaction with phenyl mercuric acetate in alkaline plasma and extracting into toluene. Back-extraction of the toluene layer with 0.1N HCl regenerates 6-MP, which is then oxidised to purine-6-sulphonate and assayed fluorimetrically. 3 This assay has been modified to measure azathioprine and a new thiopurine metabolite in plasma. 4 In a kidney transplant patient given azathioprine, 50 mg i.v., conversion to 6-MP was rapid and the plasma half-life of 6-MP was 36 min. 5 These assays are suitable for studying the pharmacokinetics of azathioprine in patients with kidney transplants. The 6-MP assay should also prove useful for studying the pharmacokinetics of the drug in patients with leukaemia. | lld:pubmed |
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| pubmed-article:40585 | pubmed:language | eng | lld:pubmed |
| pubmed-article:40585 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:40585 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:40585 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:40585 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:40585 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:40585 | pubmed:author | pubmed-author:MaddocksJ LJL | lld:pubmed |
| pubmed-article:40585 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:40585 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:40585 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:40585 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:40585 | pubmed:pagination | 273-8 | lld:pubmed |
| pubmed-article:40585 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:40585 | pubmed:meshHeading | pubmed-meshheading:40585-Hy... | lld:pubmed |
| pubmed-article:40585 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:40585 | pubmed:articleTitle | Assay of azathioprine, 6-mercaptopurine and a novel thiopurine metabolite in human plasma. | lld:pubmed |
| pubmed-article:40585 | pubmed:publicationType | Journal Article | lld:pubmed |
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