pubmed-article:4052022 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0022378 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0028941 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
pubmed-article:4052022 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
pubmed-article:4052022 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:4052022 | pubmed:dateCreated | 1985-11-4 | lld:pubmed |
pubmed-article:4052022 | pubmed:abstractText | To evaluate degradation processes of sucrase-isomaltase in adult rat jejunum, we determined enzymic activity of sucrase and isomaltase and compared it with the amount of immunoreactive sucrase-isomaltase. In rats fed or starved for 18h, killed at 10:00 h or 22:00 h, sucrase activity (expressed on the basis of total protein or of immunoreactive sucrase-isomaltase) was significantly (P less than 0.02) lower in the lower jejunum than in the upper jejunum; isomaltase activity was similar in both segments. Crossed immunoelectrophoresis demonstrated the existence of a second sucrase-isomaltase antigen reacting with anti-(sucrase-isomaltase) serum. This antigen was present in larger amounts in the lower jejunum than in the upper jejunum, exhibited immunological partial identity with the intact sucrase-isomaltase, and had isomaltase activity but no sucrase activity. Results suggest that this antigen is a degradation product of sucrase-isomaltase in which the sucrase active site has been broken down. To examine the role of pancreatic enzymes in degradation of sucrase-isomaltase, common pancreatico-biliary ducts were ligated. Within 18 h after the operation, the difference of sucrase activity between the upper and the lower jejunum disappeared and the amount of the second sucrase-isomaltase antigen markedly decreased in the lower jejunum. Our results indicate that, during the degradation of intestinal sucrase-isomaltase by the pancreatic proteinases, degradation of the sucrase active site precedes that of the isomaltase active site. | lld:pubmed |
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pubmed-article:4052022 | pubmed:language | eng | lld:pubmed |
pubmed-article:4052022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:4052022 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:4052022 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:4052022 | pubmed:month | Aug | lld:pubmed |
pubmed-article:4052022 | pubmed:issn | 0264-6021 | lld:pubmed |
pubmed-article:4052022 | pubmed:author | pubmed-author:KoldovskýOO | lld:pubmed |
pubmed-article:4052022 | pubmed:author | pubmed-author:GodaTT | lld:pubmed |
pubmed-article:4052022 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:4052022 | pubmed:day | 1 | lld:pubmed |
pubmed-article:4052022 | pubmed:volume | 229 | lld:pubmed |
pubmed-article:4052022 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:4052022 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:4052022 | pubmed:pagination | 751-8 | lld:pubmed |
pubmed-article:4052022 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:4052022 | pubmed:year | 1985 | lld:pubmed |
pubmed-article:4052022 | pubmed:articleTitle | Evidence of degradation process of sucrase-isomaltase in jejunum of adult rats. | lld:pubmed |
pubmed-article:4052022 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:4052022 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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