| pubmed-article:4046632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4046632 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:4046632 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:4046632 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:4046632 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:4046632 | lifeskim:mentions | umls-concept:C0163054 | lld:lifeskim |
| pubmed-article:4046632 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:4046632 | pubmed:dateCreated | 1985-11-15 | lld:pubmed |
| pubmed-article:4046632 | pubmed:abstractText | Despite its considerable toxicity to haemopoietic colony-forming cells, 4-hydroperoxycyclophosphamide (4-HC) has successfully been used to purge marrow of leukaemic cells before it is used to rescue patients from high-dose chemoradiotherapy. These conflicting observations indicate that haemopoietic progenitor cells that are not detected by the established colony-forming assays survive exposure to 4-HC and repopulate the marrow. The recent finding that murine spleen colony-forming cells (CFU-S) are resistant to 4-HC [Porcellini A, et al. (1983) Expl Hemat. 11 (suppl 14) 331 (abstract)] [14] also indicates that sensitivity to 4-HC can be used to distinguish primitive progenitor cells from committed progenitor cells. As part of a study on the nature of a population of blast colony-forming cells in human bone marrow, we tested their sensitivity to 4-HC to see whether they also are spared by the drug. We found that 4-HC had much less effect on the blast colony-forming cells than on the granulocyte-macrophage colony-forming cells (GM-CFC). This result suggests that the blast-colony-forming cells may be early human haemopoietic progenitor cells. | lld:pubmed |
| pubmed-article:4046632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4046632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4046632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4046632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4046632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4046632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4046632 | pubmed:issn | 0145-2126 | lld:pubmed |
| pubmed-article:4046632 | pubmed:author | pubmed-author:GoldmanJ MJM | lld:pubmed |
| pubmed-article:4046632 | pubmed:author | pubmed-author:Gordon-SmithE... | lld:pubmed |
| pubmed-article:4046632 | pubmed:author | pubmed-author:GordonM YMY | lld:pubmed |
| pubmed-article:4046632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4046632 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:4046632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4046632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4046632 | pubmed:pagination | 1017-21 | lld:pubmed |
| pubmed-article:4046632 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
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| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:meshHeading | pubmed-meshheading:4046632-... | lld:pubmed |
| pubmed-article:4046632 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4046632 | pubmed:articleTitle | 4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocyte-macrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells. | lld:pubmed |
| pubmed-article:4046632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4046632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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