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pubmed-article:4041679pubmed:abstractTextThe efficacy and affinity of nine pentatomic cyclic muscarinic agonists were determined on the guinea-pig ileum, according to the method of Furchgott & Bursztyn (1967). The efficacy and affinity of these agonists are affected differently by structural modifications. Our results suggest that a strong dipole oriented in the same direction as that of the hydroxy group of muscarine, or the presence of a polarizable atom in the same position, are important for efficacy.lld:pubmed
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pubmed-article:4041679pubmed:articleTitleAffinity and efficacy correlate with chemical structure more than potency does in a series of pentatomic cyclic muscarinic agonists.lld:pubmed
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pubmed-article:4041679pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed