| pubmed-article:4040533 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C0016601 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4040533 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:4040533 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4040533 | pubmed:dateCreated | 1985-9-4 | lld:pubmed |
| pubmed-article:4040533 | pubmed:abstractText | The effects of forskolin on phosphorylation of proteins of a 100,000 X g fraction was examined in isolated beating guinea pig hearts. Hearts were perfused with [32P] inorganic phosphate to label intracellular adenine nucleotides. Forskolin was injected into the coronary circulation and after freeze-clamping, phosphorylated proteins in a fraction were separated by sodium dodecyl sulfate-polyacrylamide gel electro-phoresis. Forskolin increased the incorporation into a 25,000 Mr protein approximately 15 fold over control. Incorporation of label was time and dose dependent and was temporally coincident with increases in developed tension. A sarcolemmal fraction prepared from perfused hearts contained a similar 25,000 Mr protein. The data provides evidence that forskolin induced inotropy is accompanied by cAMP-dependent protein kinase mediated phosphorylation. The phosphorylation may be of the same protein whose phosphorylation is associated with epinephrine-induced increase in contractility. | lld:pubmed |
| pubmed-article:4040533 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4040533 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4040533 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4040533 | pubmed:issn | 0746-3898 | lld:pubmed |
| pubmed-article:4040533 | pubmed:author | pubmed-author:DrummondG IGI | lld:pubmed |
| pubmed-article:4040533 | pubmed:author | pubmed-author:FliegelLL | lld:pubmed |
| pubmed-article:4040533 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4040533 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:4040533 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4040533 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4040533 | pubmed:pagination | 259-67 | lld:pubmed |
| pubmed-article:4040533 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:4040533 | pubmed:meshHeading | pubmed-meshheading:4040533-... | lld:pubmed |
| pubmed-article:4040533 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4040533 | pubmed:articleTitle | Effect of forskolin on phosphorylation of a 25,000 Mr protein in perfused guinea pig hearts. | lld:pubmed |
| pubmed-article:4040533 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4040533 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:4040533 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:4040533 | lld:pubmed |
