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pubmed-article:402717pubmed:abstractTextA radioimmunoassay for serum testosterone which does not require chromatographic separation was used to measure the diurnal variations in intact and orchidecomized males and intact and ovariectomized females. The intact male rhesus monkey shows a distinctive diurnal variation in serum levels of testosterone characterized by lower values during the day and a marked increase in the early evening (1900-2200 hr). The testosterone levels remain high throughout most of the lights-off period in the intact male. In contrast to the intact male, the markedly lowered serum levels of testosterone in the orchidectomized male were higher during the day and consistently showed a nadir during the early evening (2000-2200 hr). The evening nadir of testosterone levels was 51.0% lower than the 24-hr mean whereas the maximum serum level was 46.4% higher. A similar circadian pattern of testosterone was seen in both the intact and ovariectomized females. The testosterone values were higher during the day and consistently showed a nadir during the early evening. These results suggest that the adrenal secretion of testosterone varies in a diurnal pattern characterized by an early evening nadir. This adrenal pattern is overshadowed by a much larger gonadal rhythm in the intact male.lld:pubmed
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pubmed-article:402717pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:402717pubmed:year1977lld:pubmed
pubmed-article:402717pubmed:articleTitleDiurnal variations of serum testosterone levels in intact and gonadectomized male and female rhesus monkeys.lld:pubmed
pubmed-article:402717pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:402717pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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