| pubmed-article:4009712 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C0025248 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:4009712 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:4009712 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4009712 | pubmed:dateCreated | 1985-8-1 | lld:pubmed |
| pubmed-article:4009712 | pubmed:abstractText | We have studied further the genes for trypanosomal variant surface glycoproteins expressed during a chronic infection of rabbits with Trypanosoma brucei, strain 427. We show that there are three closely related chromosomal-internal isogenes for VSG 121; expression of one of these genes is accompanied by the duplicate transposition of the gene to a telomeric expression site, also used by other chromosome-internal VSG genes. The 3' end of the 121 gene is replaced during transposition with another sequence, also found in the VSG mRNAs of two other variants. We infer that an incoming VSG gene duplicate recombines with the resident gene in the expression site and may exchange ends in this process. The extra expression-linked copy of the 121 gene is lost when another gene enters the expression site. However, when the telomeric VSG gene 221 is activated without duplication the extra 121 gene copy is inactivated without detectable alterations in or around the gene. We have also analysed the VSG genes expressed very early when trypanosomes are introduced into rats or tissue culture. The five genes identified in 24 independent switching events were all found to be telomeric genes and we calculate that the telomeric 1.8 gene has a 50% chance of being activated in this trypanosome strain when the trypanosome switches the VSG that is synthesized. We argue that the preferential expression of telomeric VSG genes is due to two factors: first, some telomeric genes reside in an inactive expression site, that can be reactivated; second, telomeric genes can enter an active expression site by a duplicative telomere conversion and this process occurs more frequently than the duplicative transposition of chromosome-internal genes to an expression site. | lld:pubmed |
| pubmed-article:4009712 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4009712 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4009712 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4009712 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4009712 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4009712 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:4009712 | pubmed:author | pubmed-author:MichelsP APA | lld:pubmed |
| pubmed-article:4009712 | pubmed:author | pubmed-author:BorstPP | lld:pubmed |
| pubmed-article:4009712 | pubmed:author | pubmed-author:LiuA YAY | lld:pubmed |
| pubmed-article:4009712 | pubmed:author | pubmed-author:BernardsAA | lld:pubmed |
| pubmed-article:4009712 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4009712 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:4009712 | pubmed:volume | 182 | lld:pubmed |
| pubmed-article:4009712 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4009712 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4009712 | pubmed:pagination | 383-96 | lld:pubmed |
| pubmed-article:4009712 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:4009712 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4009712 | pubmed:articleTitle | Trypanosome variant surface glycoprotein genes expressed early in infection. | lld:pubmed |
| pubmed-article:4009712 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4009712 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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