| pubmed-article:3997873 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3997873 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:3997873 | lifeskim:mentions | umls-concept:C0026238 | lld:lifeskim |
| pubmed-article:3997873 | lifeskim:mentions | umls-concept:C0000424 | lld:lifeskim |
| pubmed-article:3997873 | lifeskim:mentions | umls-concept:C1158366 | lld:lifeskim |
| pubmed-article:3997873 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:3997873 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:3997873 | pubmed:dateCreated | 1985-7-25 | lld:pubmed |
| pubmed-article:3997873 | pubmed:abstractText | The effects of several short-chain mercapto acids on the rate of respiration supported by either palmitoylcarnitine, octanoate, or pyruvate was studied with coupled rat heart mitochondria. 3-Mercaptopropionic acid was found to be a potent inhibitor of respiration sustained by palmitoylcarnitine or octanoate, whereas under identical conditions respiration with pyruvate as a substrate was unaffected. 2-Mercaptoacetic acid also inhibits palmitoylcarnitine-supported respiration, but only at much higher concentrations of the inhibitor. 2-Mercaptopropionic acid has virtually no effect. Incubation of mitochondria with 3-mercaptopropionic acid did not cause the irreversible inactivation of any beta-oxidation enzyme. Since 3-mercaptopropionic acid did not inhibit beta-oxidation in uncoupled mitochondria, it appears that this compound must first be metabolized in an energy-dependent reaction before it becomes inhibitory. 3-Mercaptopropionyl-CoA and three of its S-acyl derivatives, all of which are likely mitochondrial metabolites of 3-mercaptopropionic acid, were tested for their capacity to inhibit the individual enzymes of beta-oxidation. 3-Mercaptopropionyl-CoA inhibits only acyl-CoA dehydrogenase, whereas S-myristoyl-3-mercaptopropionyl-CoA inhibits reversibly several beta-oxidation enzymes. All observations together lead us to suggest that the inhibition of beta-oxidation by 3-mercaptopropionic acid in coupled rat heart mitochondria is most likely a consequence of the reversible inhibition of acyl-CoA dehydrogenase by long-chain S-acyl-3-mercaptopropionyl-CoA thioesters and possibly by 3-mercaptopropionyl-CoA. | lld:pubmed |
| pubmed-article:3997873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3997873 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3997873 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3997873 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3997873 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:3997873 | pubmed:author | pubmed-author:SchulzHH | lld:pubmed |
| pubmed-article:3997873 | pubmed:author | pubmed-author:CuebasDD | lld:pubmed |
| pubmed-article:3997873 | pubmed:author | pubmed-author:SabbaghEE | lld:pubmed |
| pubmed-article:3997873 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3997873 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:3997873 | pubmed:volume | 260 | lld:pubmed |
| pubmed-article:3997873 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3997873 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3997873 | pubmed:pagination | 7337-42 | lld:pubmed |
| pubmed-article:3997873 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:meshHeading | pubmed-meshheading:3997873-... | lld:pubmed |
| pubmed-article:3997873 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3997873 | pubmed:articleTitle | 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. | lld:pubmed |
| pubmed-article:3997873 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3997873 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3997873 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3997873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3997873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3997873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3997873 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3997873 | lld:pubmed |
