| pubmed-article:3989726 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3989726 | lifeskim:mentions | umls-concept:C1882628 | lld:lifeskim |
| pubmed-article:3989726 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:3989726 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:3989726 | lifeskim:mentions | umls-concept:C0052972 | lld:lifeskim |
| pubmed-article:3989726 | pubmed:dateCreated | 1985-6-20 | lld:pubmed |
| pubmed-article:3989726 | pubmed:abstractText | BaCl2, applied serosally, caused a rise in the p.d. and short-circuit current (s.c.c), and a decrease in tissue resistance in stripped sheets of rat colon. This response was dose dependent. Mucosal application of BaCl2 was without effect. The BaCl2-induced rise in s.c.c. was inhibited by reducing the serosal Na+ concentration to 25 mM. Lowering the mucosal Na+ concentration was without effect. Ouabain (10(-3) M in serosal fluid) and furosemide (10(-3) M in serosal fluid) both reduced the rise in s.c.c. induced by BaCl2. Flux determinations indicated that BaCl2 inhibited Na+ absorption and stimulated Cl- secretion by the colon. In vivo, BaCl2 increased fluid accumulation within the colonic lumen, an effect that was associated with a rise in the transcolonic p.d. Increasing the serosal K+ concentration to 20 mM reduced the responses to BaCl2, acetylcholine and theophylline, and this could not be entirely accounted for by the concomitant reduction in the serosal Na+ concentration. As high serosal K+ did not mimic the secretory response it would appear that BaCl2 does not act by blocking K+ channels. The rise in s.c.c. induced by BaCl2 was not reduced by Ca2+-free conditions, but it was inhibited by 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) and trifluoperazine. BaCl2 did not alter cyclic AMP production by colonic scrapes. It is concluded that BaCl2 induces colonic secretion by the release of intracellular Ca2+, which then combines with calmodulin to activate the secretory process. | lld:pubmed |
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| pubmed-article:3989726 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3989726 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3989726 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3989726 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3989726 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3989726 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:3989726 | pubmed:author | pubmed-author:HardcastleJJ | lld:pubmed |
| pubmed-article:3989726 | pubmed:author | pubmed-author:HardcastleP... | lld:pubmed |
| pubmed-article:3989726 | pubmed:author | pubmed-author:NobleJ MJM | lld:pubmed |
| pubmed-article:3989726 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3989726 | pubmed:volume | 361 | lld:pubmed |
| pubmed-article:3989726 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3989726 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3989726 | pubmed:pagination | 19-33 | lld:pubmed |
| pubmed-article:3989726 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3989726 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3989726 | pubmed:articleTitle | The secretory action of barium chloride in rat colon. | lld:pubmed |
| pubmed-article:3989726 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3989726 | pubmed:publicationType | In Vitro | lld:pubmed |
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