| pubmed-article:3982225 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3982225 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3982225 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3982225 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3982225 | lifeskim:mentions | umls-concept:C0016733 | lld:lifeskim |
| pubmed-article:3982225 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:3982225 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:3982225 | pubmed:dateCreated | 1985-5-20 | lld:pubmed |
| pubmed-article:3982225 | pubmed:abstractText | D-2 dopamine receptors and serotonin receptors in the frontal cortex of rat and human were labelled with 3H-spiroperidol. The D-2 receptors were then distinguished in 4 ways. Dissociation of spiroperidol was biphasic, indicating two populations of sites. Cinanserin in competition with 3H-spiroperidol exhibited high (75%) and low (25%) affinity sites. Dopamine and LY 141865 in competition with 1.25 nM 3H-spiroperidol exhibited high (20-25%) and low (80-75%) affinity sites in the absence of cinanserin, while in the presence of 300 nM cinanserin only the high affinity sites remained. Lesioning of the dopaminergic meso-cortical pathway increased the number of cinanserin-resistant sites by 26%. Thus 3H-spiroperidol binding in the presence of cinanserin can be used to selectively label D-2 receptors in the frontal cortex. | lld:pubmed |
| pubmed-article:3982225 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3982225 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3982225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3982225 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3982225 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3982225 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:3982225 | pubmed:author | pubmed-author:PotterL TLT | lld:pubmed |
| pubmed-article:3982225 | pubmed:author | pubmed-author:LiskowskyD... | lld:pubmed |
| pubmed-article:3982225 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3982225 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:3982225 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:3982225 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3982225 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3982225 | pubmed:pagination | 1551-9 | lld:pubmed |
| pubmed-article:3982225 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:meshHeading | pubmed-meshheading:3982225-... | lld:pubmed |
| pubmed-article:3982225 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3982225 | pubmed:articleTitle | D-2 dopamine receptors in the frontal cortex of rat and human. | lld:pubmed |
| pubmed-article:3982225 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3982225 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3982225 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3982225 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3982225 | lld:pubmed |
