| pubmed-article:3972233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3972233 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:3972233 | lifeskim:mentions | umls-concept:C0043515 | lld:lifeskim |
| pubmed-article:3972233 | lifeskim:mentions | umls-concept:C0028978 | lld:lifeskim |
| pubmed-article:3972233 | lifeskim:mentions | umls-concept:C1704419 | lld:lifeskim |
| pubmed-article:3972233 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3972233 | pubmed:dateCreated | 1985-4-18 | lld:pubmed |
| pubmed-article:3972233 | pubmed:abstractText | The acute and long-term effects of omeprazole on gastric acid secretion were examined in 11 patients with Zollinger-Ellison syndrome. Basal gastric acid secretion was inhibited by 50% 3 h after a single 60-mg dose of omeprazole and 78% 4 h after administration of omeprazole. Patients were treated with a single daily dose of omeprazole, and the dose requirement was defined as the lowest dose of omeprazole that would reduce gastric acid secretion to less than 10 mEq/h during the last hour before the next dose. The mean daily dose requirement was 70 mg (range 20-160 mg). Ten of the 11 patients were given omeprazole once a day and 1 patient required omeprazole every 12 h. When omeprazole was discontinued after several months of therapy, mean basal gastric acid secretion was inhibited by greater than 50% 48 h after administration of omeprazole. Omeprazole continued to inhibit gastric acid secretion during 1-9 mo of therapy and patients remained free of toxicity or side effects related to omeprazole. Omeprazole is a highly effective inhibitor of gastric acid secretion in patients with Zollinger-Ellison syndrome. Because of its potency and long duration of action, omeprazole offers an advance in convenient medical therapy for Zollinger-Ellison syndrome compared with the histamine H2-receptor antagonists. | lld:pubmed |
| pubmed-article:3972233 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3972233 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3972233 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3972233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3972233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3972233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3972233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3972233 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3972233 | pubmed:issn | 0016-5085 | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:GardnerJ DJD | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:MatonP NPN | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:HowardJ MJM | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:JensenR TRT | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:CorneliusM... | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:CollenM JMJ | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:CherneyJ HJH | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:McArthurK EKE | lld:pubmed |
| pubmed-article:3972233 | pubmed:author | pubmed-author:CiarleglioC... | lld:pubmed |
| pubmed-article:3972233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3972233 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:3972233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3972233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3972233 | pubmed:pagination | 939-44 | lld:pubmed |
| pubmed-article:3972233 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
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| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:meshHeading | pubmed-meshheading:3972233-... | lld:pubmed |
| pubmed-article:3972233 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3972233 | pubmed:articleTitle | Omeprazole: effective, convenient therapy for Zollinger-Ellison syndrome. | lld:pubmed |
| pubmed-article:3972233 | pubmed:publicationType | Journal Article | lld:pubmed |
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